Lymphoid Neoplasms Flashcards
malignancy of lymphocytes
often form a mass
involve lymph nodes
lymphomas
enlarged painless lymph nodes
fever, fatigue, chills, night sweats
lymphoma
Reed Sternberg cells present on tissue biopsy
Hodgkin lymphoma
derive from B cells
CD15 and CD30
Reed-sternberg cells
Hodgkin lymphoma
malignant cell= Reed-Sternberg cell
B symptoms common
hypercalcemia (from macrophages)
Hodgkin lymphoma
cervical lymphadenopathy commonly seen with this
Hodgkin Lymphoma
Hodgkin lymphoma
rare variant of Hodgkin lymphoma
malignant cells: LP (popcorn cells)
express CD20
Nodular Lymphocyte Predominant Hodgkin Lymphoma
most common type of Hodgkin lymphoma
tumor forms fibrous tissue surrounding itself and creating nodules
Nodular Sclerosing Hodgkin Lymphoma
more common in women
mediastinal mass on CXR
reed-sternberg cells seen in clear space (lacunar variant)
nodular sclerosing hodkgin lymphoma
hodgkin lymphoma type with many different cells
Mixed Cellularity
Lymphocyte rich type Hodgkin lymphoma has what prognosis
excellent
Lymphocyte depleted Hodgkin lymphoma has what prognosis
poor
localized; orderly spread from node to node
Hodgkin Lymphoma
multiple peripheral sites
noncontiguous spread
extranodal involvement common
Non-Hodgkin lymphoma
most common treatment for Hodgkin lymphoma
ABVD chemotherapy
B and T cell malignancies (mostly B cells)
malignant cells obliterate lymph node architecture
Non-Hodgkin lymphoma
most common Non-Hodgkin lymphoma
B cell malignancy (expresses CD19 and CD20)
median age of 64 yrs
AIDS defining malignancy
diffuse B cell lymphoma
to treat diffuse B cell lymphoma
Rituximab (monoclonal CD20 antibody)
B cell malignancy (express CD19, CD20)
t(14;18) translocation!!
overexpression of BCL2
follicular lymphoma
median age 65 yrs
indolent course
follicular lymphoma
lymphoma vs reactive lymphadenopathy
LAD will have macrophages b/c cell death
lymphoma will have BCL2 staining
B cell malignancy
expresses CD5 and CD20
median age 68
poor prognosis
Mantle Cell Lymphoma
t(11;14) translocation
overexpression of cyclin D1
mantle cell lymphoma
____zone forms and expands in setting of chronic inflammation
marginal zone
lymphoma in chronic inflammatory disorders
marginal zone lymphoma
CD20 and CD5
negative for cyclin D1
lymphocyte count <5000
small lymphocytic lymphoma
B cell malignancy
very aggressive
starry sky morphology
EBV
C-myc translocation
Burkitt’s Lymphoma
“starry sky”
Burkitts lymphoma
endemic form: children and mass in mandible
sporadic form: children and abdominal mass
Burkitt’s lymphoma
CD4+ T cell malignancy
HTLV-1 infection
skin lesions
T cell leukemia/lymphoma
skin disorder of malignant T cells
localized disease: Mycosis Fungoides
diffuse disease: Sezary syndrome
Cutaneous T cell lymphoma
Sezary cells (seen in cutaneous T cell lymphoma)
