Amyloidosis Flashcards
pathologic aggregate of amyloid proteins (damages tissues)
Amyloid
beta amyloid buildup seen in what
Alzheimers
Amylin deposits in pancreas
type II diabetes
diffuse amyloid deposition
amyloidosis
AL: light chains
primary amyloidosis
AA: serum amyloid A
secondary amyloidosis
beta-2 microglobulin in ____-related amyloidosis
dialysis-related amyloidosis
transthyretin seen in ____-related systemic amyloidosis
age-related
normal transthyretin seen in what amyloidosis
age-related
abnormal transthyretin seen in what
familial (hereditary) amyloidosis
pink on a standard biopsy
amyloid
congo red stain: pink under ordinary light
amyloid
congo red stain: shows apple-green birefringence under polarized light
amyloid
amyloid forms _____ sheets that is responsible for congo red staining
beta-pleated
plasma cell malignancy
amyloid formed from light chains
monoclonal plasma cells on bone marrow biopsy
AL Amyloidosis
occurs in chronic inflammatory conditions (RA, ankylosing spondylitis, IBD)
serum amyloid A proteins (SAA)
AA amyloidosis
B2 microglobulin
complication of renal failure
dialysis does not effectively remove B2 microglobulin
shoulder pain
carpal tunnel syndrome
Dialysis-related Amyloidosis
pt on dialysis develops pain in shoulder and/or wrist
Dialysis-related amyloidosis
Age-related amyloidosis
pt born with this but takes years for amyloid to buildup and sx’s to occur
Familial Amyloidosis
rare
Amyloidosis
most commonly involved organ: kidneys
leads to proteinuria and nephrotic syndrome
Amyloidosis
in the heart, leads to restrictive cardiomyopathy and arrhythmias
Amyloidosis
how to biopsy for Amyloidosis
abdominal fat pad
