Sos Reproductive ILA Flashcards
1
Q
A
genital warts (condyloma)
2
Q
genital warts are caused by what
A
HPV 6 or 11
3
Q
A
koilocytes (histopath of wart)
4
Q
A
SCC
5
Q
what strains of HPV can progress to SCC
A
HPV 16 or 18
6
Q
dysplasia
A
leukoplakia
7
Q
dysplasia
A
erythroplakia
8
Q
A
squamous metaplasia
9
Q
A
squamous dysplasia
10
Q
A
SCC
11
Q
Greater than 70% of men are older than 65 yrs of age
Most common cancer of the prostate
A
prostatic adenocarcinoma
12
Q
elevated PSA
gleason grade for cancer
A
prostatic adenocarcinoma
13
Q
arises from prostatic intraepithelial neoplasia (dysplasia)
A
prostatic adenocarcinoma
14
Q
normal what
A
prostate epithelium
15
Q
prostate grade
A
III
16
Q
prostate grade
A
high
17
Q
gland disappearance
A
prostate adenocarcinoma
18
Q
most likely place for prostate adenocarcinoma to metastasize
A
bone
19
Q
A
gonadal germ cell tumors
20
Q
gonadal neoplasm
PLAP +
A
seminoma
21
Q
gonadal neoplasm
AFP+
A
yolk sac tumor
22
Q
gonadal neoplasm
beta-hCG +
A
choriocarcinoma
23
Q
gonadal neoplasm
androgen +
A
Leydig cell tumor
24
Q
gonadal neoplasm
CD20 +
A
lymphoma
25
gonadal neoplasms
cytokeratin +
sertoli cell tumor
teratoma
26
most common germ cell tumor
15-34 yrs
PLAP+
b-hCG +
seminoma
27
Consists of two to three fetal cell layers (endoderm, mesoderm, ectoderm) can see teeth or hair or other organ tissue
teratoma
28
teratoma composed of thyroid tissue
struma ovarii
29
can secrete AFP and hCG
arise from immature epithelial cells
mixed cellular architecture
rapid spread out of testis to blood vessels
embryonal carcinoma
30
Most common malignant germ cell tumor in children under the age of 3
AFP +
Yolk sac tumor
31
schiller-duval bodies
Yolk sac tumor
32
Rare malignant neoplasm composed of cytotrophoblasts and syncytiotrophoblasts
choriocarcinoma
33
Most commonly occur in woman after an abnormal pregnancy
Can occur nongestationally in gonads
choriocarcinoma
34
beta-hCG +
choriocarcinoma
35
Can produce hyperthyroidism, TSH reduced and T4 elevated
Hematogenous metastatic spread to lungs
choriocarcinoma
36
choriocarcinoma
37
rare
ave age is 45
cytokeratin +
sertoli cell tumor
38
Causes precocious puberty in children and gynecomastia in adult males
Produce androgens
Leydig cell tumor
39
Bimodal age of 5-10 years and 30-60 years
Cytoplasmic and nuclear inclusions
Leydig cell tumor
40
Leydig cell tumor
41
Most common in males > 60 yrs of age
Often bilateral and a large B-cell lymphoma
CD20+
testicular lymphoma
42
testicular lymphoma
43
80% of ovarian tumors
surface epithelial ovarian neoplasia
44
most common subtypes of surface epithelial ovarian neoplasia
serous and mucinous
45
common ovarian neoplasia in premenopausal females
serous cystadenoma
46
common ovarian neoplasia in postmenopausal females
serous cystadenocarcinoma
47
mucinous cystadenoma
48
mucinous cystadenocarcinoma
49
_____ carriers have increased risk of serous carcinomas of the ovaries and breast cancer
BRCA1
50
serum tumor marker used for recurrence
CA-125
51
are rare surface epithelial-stromal tumor hybrid, often benign and found incidentally
brenner tumor
52
Most common malignant germ cell tumor in females
dysgerminoma
53
Male counterpart is the seminoma
fried egg appearance
dysgerminoma
54
Most common sex cord-stromal tumor most commonly in females > 50 yrs of age
granulosa cell tumor
55
Produces estrogen/progesterone and leads to uterine bleeding
Call-Exner bodies
granulosa cell tumor
56
ovarian fibroma, ascites, pleural effusion
Meigs syndrome
57
Meigs syndrome
58
fibroma
59
ovarian masses with signet ring adenocarcinoma on histopath
Krukenberg tumor (gastric carcinoma that metastasized to ovaries)
60
Very rare, typically a mucinous tumor of the appendix that metastasis to the ovary with massive implantation within the abdomen (multiple organs)
Pseudomyxoma Peritonei
61
vulvar leukoplakia
62
Risk factors include early age sexual intercourse and multiple partners
HPV 16 and 18
vulvar carcinoma
63
Non-HPV vulvar cancer associated with long-standing _____
lichen sclerosis
64
ulcerated mass of vulva think what
vulvar SCC
65
Rare slow growing cancer related to Paget disease of the breast
Found in the skin of the vulva and anus
Most commonly in postmenopausal females
Also can be found in older men
extramammary paget disease
66
Extramammary Paget disease is a high grade dysplasia/adenocarcinoma with no underlying ____
carcinoma
67
Paget disease of the _____ is a high grade dysplasia with an underlying cancer almost 100% of the time
breast
68
a progression of vulvar/cervical cancer
vaginal SCC
69
complication of DES-associated vaginal adenosis (exposure to DES in utero)
clear cell adenocarcinoma of vagina
70
Rare malignant mesenchymal tumor consisting of immature skeletal muscle with a poor prognosis and recurrence
embryonal rhabdomyosarcoma
71
Presents as grape-like mass in children < 5yrs of age, prolapsed vaginal mass with bleeding
embryonal rhabdomyosarcoma
72
another term for embryonal rhabdomyosarcoma
sarcoma botryoides
73
most common site of HPV infection of cervix (where pap smear is taken from)
transformation zone
74
HPV E6 targets____ and E7 targets ____
p53
Rb
75
cervical changes from L to R
normal on L
CIN 2/3 on R
76
koilocytes
CIN 1
77
90% of cervical cancers arising from the transformation zone with 90% of these cancers influenced by HPV ___ and ___
16 and 18
78
cervical ____
SCC
79
normal what
endometrium
80
high grade what
endometrial dysplasia
81
Most common cancer of the endometrium in postmenopausal females
Most common malignant cancer of the female genital tract
endometrial adenocarcinoma
82
A female with Lynch syndrome have a high risk of ______ cancers in their 40-50s
ovarian and endometrial (on top of colorectal)
83
Proliferation of myometrial smooth muscle
Most common benign female genital neoplasm, often multiple
Common in premenopausal females
Leiomyoma (fibroid)
84
leiomyoma (fibroids)
85
Malignant proliferation of smooth muscle myometrium
Arises de novo
leiomyosarcoma
86
______ do not become leiomyosarcoma
leiomyomas
87
Often found in postmenopausal females
Gross findings include necrosis or hemorrhage
Microscopic findings include cell atypia, mitotic figures and necrosis
Leiomyosarcoma
