Plasma cell disorders Flashcards
derived from B cells that get activated by immune system and begin secreting antibodies
found in medulla of lymph node
plasma cells
malignancy of plasma cells
median age 66
excess production of immunoglobulin
multiple myeloma
dependent on IL-6
multiple myeloma
most abundant immunoglobulin produced by multiple myeloma
IgG
excess light chains can occur with this
can lead to renal damage and AL amyloidosis
multiple myeloma
“M spike”
Multiple myeloma
bone pain/fractures
hypercalcemia (due to bone breakdown)
renal failure
anemia
infections
multiple myeloma
punched out lytic lesions on xrays in adults
osteoclast-mediated bone resorption
fractures
elevated serum calcium
Multiple Myeloma
renal failure in multiple myeloma caused by what
light chains and hypercalcemia
PCT capacity exceeded, light chains reach distal tubule
obstructing casts and light chains in urine (Bence jones proteins)
renal failure in multiple myeloma
renal failure in multiple myeloma
normocytic, normochromic anemia (bone marrow replacement by plasma cells) and low EPO due to renal failure
Multiple Myeloma
decreased production of normal immunoglobulins (decreased humoral immunity)
increase in infections due to multiple myeloma
Rouleaux formation seen in what (due to elevated protein levels in plasma and cause RBCs to stick together)
Multiple myeloma
asymptomatic plasma cell disorder
no end organ damage
can progress to multiple myeloma
monoclonal gammopathy of undetermined signifigance (MGUS)
B cell lymphoma
tumor cells differentiate into plasma cells
produce IgM antibodies
hyperviscosity syndrome
Waldenstrom Macroglobinemia (lymphoplasmacytic lymphoma)
no osteolytic bone lesions (compare to MM)
M spike from IgM
Waldenstrom Macroglobulinemia (lymphoplasmacytic lymphoma)
HA,s dizziness, coma
visual impairement
hyperviscosity syndrome
bone-based lytic tumor
derived from neoplastic plasma cells
slowly progressive
myeloma
tissue mass composed of neoplastic myeloid cells
myeloid sarcoma
multiple lesions throughout skeleton and bone marrow seen in this myeloma
atypical plasma cells
plasma cell myeloma (multiple myeloma)
one or two lesions seen in this type of plasma neoplasia
plasmacytoma
mean age 60-70
multiple lytic bony lesions
bone pain
hypercalcemia
renal failure
infections
plasma cell myeloma (multiple myeloma)
Abnormal _____ cells can secrete IL-6 and have receptors for IL-6
plasma cells (multiple myeloma)
Sort of precursor to myeloma
One lesion of bone (soft tissue tumor)
Indolent
Excision can be curative
plasmacytoma
