Transfusion Medicine Flashcards
Organism that is the most common culprit causing septic transfusion reactions? ( transfusion associated bacterial sepsis)
Pseudomonas fluorescens
And Yersinia enterocolitica
Which of the following red cell antigens is unchanged when exposed to proteolytic (ficin) enzymes?
Enhanced: P, Lewis, Kidd and Rh
Destroyed: Fy and MNS
Which of the products other than red cells always needs ABO typing and crossmatching ?
Granulocytes
What is the most immunogenic blood group after D antigen ?
Kell
K> Jka > Fya
Storage conditions ————————— Platelets Granulocytes Red blood cells Frozen red blood 🩸 cells Thawed plasma
Platelets: 20-24 with agitation Granulocytes : 20-24 without agitation Red blood cells: 1-6 deg C Frozen red blood 🩸 cells : - 65 deg C Thawed plasma : 1-6 deg C
WinRho- uses and testing needs
Is an IV form of RhIg which is used to treat ITP.
Effective in D pos with an intact spleen
Needs prior type and screen testing
How does storage time change after washing
Leukoreduced RBCs
Leukoreduced platelets
After washing:
Leukoreduced RBCs - 24 hours
Leukoreduced platelets - 4 hours
How often do we need dose verification for cesium 137 irradiation of blood products?
AABB standards : once a year
Other: cobalt 60 - once in 6 months
How much iron does a whole blood unit contain
Whole blood is 500mls contains approximately 200 mg of blood.
What is Evans syndrome?
Combination of AIHA and ITP. DAT - IgG+, complement- neg and a pan reactive eluate.
Vaccine deferral revision
Toxoid, synthetic or killed - NO deferral
Recombinant vaccines- NO deferral
Live attenuated viral and bacterial vaccine- 2 week deferral
Live attenuated viral (some)vaccine - 4 week deferral ( German M, chicken pox)
Small pox: 21 days or 2 months if scab was removed and did not fall off
Hep B immune globulin and unlicensed vaccines- 12 MONTHS deferral
Shelf life of RBCs
AS-1, AS-3, AS-5 and AS-7: 42 days
CPD and CP2D: 21 days
CPDA-1: 35 days
Irradiation: 28 days or expiry whichever is shorter
