Molecular

Question 1

The ETV6-NTRK3 translocation is associated with which of the following ?

Answer 1

t(12;15) translocation-

Congenital mesoblastic nephroma
Infantile fibrosarcoma
Salivary gland MASC
Secretory of the breast

Question 2

EWSR1 rearrangement is seen in which salivary gland carcinoma

Answer 2

Hyalinizing clear cell carcinoma

Question 3

Clear cell meningioma is associated with a germ line mutation of which of the genes ?

Answer 3

SMARCE1 - asso with spinal and cranial clear cell meningioma

Question 4

EGFR inhibitors and resistance

Answer 4

Resistance to EGFR- TKIs is due to emergence of T790M mutation

Question 5

What is EGFR L858R mutation associated with

Answer 5

Sensitivity to EGFR inhibitor

Question 6

What type of mutation in GIST is associated with primary resistance to therapy with imagining?

Answer 6

PDGFRA D842V mutation leads to imatinib resistance…..

KIT exon 11 and 9 mutations typically have good response to imatinib.

Question 7

What is the most common recurrent alteration in lung squamous cell carcinoma with a potential for targeted therapy ?

Answer 7

FGFR1 in 17% of squamous cell ca lung.

Question 8

Rearrangement seen in Hibernoma

Answer 8

11q13-21 in hibernoma

Question 9

Rearrangements in aneurysmal bone cyst of soft tissue

Answer 9

USP6 rearrangements (17p13)

Question 10

Mesenchymal chondrosarcoma fusion

Answer 10

Head and neck of young people HEY1-NCOA2 fusion due to del(8)(q13.3q21.1).

Question 11

Neurofibroma in NF 2 shoes inactivation of

Answer 11

CDKN2

Question 12

Most common mutation in NIFTP?

Answer 12

RAS is most common

THADA and PAX8/PPARG also seen but less common

Question 13

Mutation in which of the following genes would be expected to be present in sinonasal mucosal melanoma?

Answer 13

KIT 25% of mucosal melanomas , 6-8% of cutaneous and less than 1 % uveal melanomas

BAP1, GNAQ and GNA11- seen in uveal melanomas