CNS And Eye

Question 1

Mets to eye 👁 is usually from …

Answer 1

Choroid 81% (due to its vascularity) > iris 9% > optic disk 5% > ciliary body ~3%

Breast (47%)
Lung 21%
GI tract 4%
Renal 2%

Question 2

Sarcoidosis involving eyes

Answer 2

15-50% occurs in eye.
Uveitis - most common presentation
Inflammatory nodules- in conjunctiva and pupillary margin called Koeppe nodule.

Question 3

Medulloepithelioma of the eye features

Answer 3

DICER mutation (like pleuropulm blastema)

Malignancy from embryonic cells of optic cup - medullary ep and culinary body.
Pigmented cystic mass, FW and HW rosettes+
Hyteroplastic tissue *** (classic feature)- cartilage, neural tissue, smooth muscle, rgabdomyoblasts

Question 4

SEGA features

Answer 4

Associated with tuberous sclerosis
Benign , slow growing
Lateral ventricular walls
Micro: large ganglioid astrocytes

Question 5

Medulloblastoma associated with syndrome

Answer 5

Gorlin $ ( nevoid nasal cell carcinoma syndrome)
Autosomal dominant
Patched-1 (PTCH-1) gene chromosome 9
Sonic hedgehog pathway

Desmoplastic nedulloblastoma most associated with NBCC$.

Question 6

Conditions associated with neutrophils in the CSF:

Answer 6

Acute bacterial meningitis
CMV radiculopathy
Toxoplasma meningoencephalitis
Peripheral blood contamination

Question 7

Coccidioides immitis infection shows which type of inflammatory cells

Answer 7

Eosinophils are seen in CSF

Question 8

Inclusions seen in Parkinson’s?

Answer 8

Lewy bodies
Alpha- synuclein

Others:
TDP43 and bunina bodies in ALS, beta- amyloid and tau in Alzheimer’s