Toxoplasmosis

Question 1

Define toxoplasmosis in pregnancy.

Answer 1

Infection by toxoplasmosis gondii

Question 2

What is the aetiology of toxoplasmosis in pregnancy?

Answer 2

FOR transmission (infected meat and cat faeces)

Question 3

What are the risk factors for toxoplasmosis?

Answer 3

Household cats

Rural areas

Brie

Question 4

Summarise the epidemiology of toxoplasmosis in pregnancy.

Answer 4

1/2000 pregnancies

Question 5

What are some symptoms of toxoplasmosis in pregnancy?

Answer 5

Fever

Malaise

Arthralgia

Often asymptomatic

Question 6

What are the signs of toxoplasmosis in pregnancy?

Answer 6

None

?Lymphadenopathy

Question 7

What are some investigations for toxoplasmosis in pregnancy?

Answer 7

Bloods: IGM, IgG

USS: Fetal abnormality scan

Other: Amniocentesis to detect fetal infection

Question 8

What is the management for toxoplasmosis in pregnancy?

Answer 8

ABX: Spiramycin (reduces vertical tranmsission)

Termination: May offer TOP if USS evidence of fetal infection

Question 9

What are the complications associated with toxoplasmosis in pregnancy? What is the prognosis of toxoplasmosis in pregnancy?

Answer 9

Miscarriage, PTL, fetal death, congenital toxoplasmosis (hydrocephalus, retinochondtiritis, intracranial calcifications, IUGR, Heptaosplenomegaly, Thrombocytopenia, rash)

PGX depends on severity of congential toxoplasmosis.