CMV Flashcards

1
Q

Define CMV in pregnancy.

A

Common infection in pregnancy associated with severe congenital syndrome in the fetus.

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2
Q

What is the aetiology of CMV in pregnancy?

A

Transmission: Sexual, blood, saliva, urine, vertical.

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3
Q

What are the risk factors for CMV in pregnancy?

A

Higher SES

Immunosuppresson (HIV)

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4
Q

Summarise the epidemiology for CMV in pregnancy.

A

50% immunity in pregnant women. 1% seronegative pregnant women will contract it.

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5
Q

What are the symptoms of CMV in pregnancy?

A

Often asymptomatic

?Fever, malaise, fatigue

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6
Q

What are the signs of CMV in pregnancy.

A

No clinical signs, lymphadenopathy.

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7
Q

What investigations are performed for CMV in pregnancy?

A

Blood: CMV IgM (current)/IgG (past infection)

USS: Fetal anomaly scan

Other: Amniocentesis for CMV PCR (6-9wk after primary infection)

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8
Q

What is the management for CMV in pregnancy?

A

No treatment to prevent transmission to fetus.

May offer termination of pregnancy if evidence of neural damage.

Neonatal ganacyclovir can attenuate hearing impairment.

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9
Q

What are the complications associated with CMV in pregnancy? What is the prognosis of CMV in pregnancy?

A

High risk of miscarriage, stilbirth, congenital CMV, IUGR, microcephaly, intracerebral calcification, blind, sensorineural deafness, hepatosplenomegaly, skin rash, pneumonitis, mental retardation.

40% rate of transmission to fetus if infected mother. Of these, 10% develop fetal CMV syndrome. 90% of children with this develop neurological development delay.

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