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Pharma > Toxicology > Flashcards

Toxicology Flashcards

1
Q

Benzodiazepine

A

Flumazenil

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2
Q

Heparin

A

Protamine sulfate

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3
Q

Iron

A

Deferroxamine

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4
Q

Opiod / Narcotic

A

Naloxone

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5
Q

Acute Mercury Poisoning

A

Dimercaprol

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6
Q

Wilson’s Disease

Cu metabolism

A

Penicillamine

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7
Q

Chronic Mercury Poisoning condition

A

Minamata Disease

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8
Q

Lead

A

EDTA

Dimercaprol

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9
Q

Arsenic

A

Dimercaprol

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10
Q

Organophosphate
Insecticide (Malathion, Parathion)

Acute

A

Pralidoxime

reverses both PNS (paralysis) and CNS but at acute cases only

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11
Q

Organophosphate

Insecticide (Parathion/Malathion)

Chronic

A

Atropine

CNS effects but can’t reverse paralysis

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12
Q

Acetaminophen

Paracetamol

A

N Acetylcysteine

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13
Q

Acetaminophen Paracetamol Toxicity causes

A

Centrilobular
Hepatic
Necrosis

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14
Q

Isoniazid INH

A

Pyridoxime B6

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15
Q

Sodium Nitroprusside condition

A

Cyanide / Thiocyanate Toxicity

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16
Q

Sodium Nitroprusside Antidote

A

Sodium Thiosulfate

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17
Q

Blockade of Complex IV ETC

Cytochrome oxidase

A

Cyanide Toxicity

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18
Q

Fibrinolytic toxicity

A

Aminocaproic acid

Tranexamic acid

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19
Q

Digoxin Induced Arrhythmia

A

Lidocaine

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20
Q

Beta Blocker overdose

A

Glucagon

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21
Q

Sufonylurea overdose

A

Ocreotide

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22
Q

Clonidine overdose

A

Naloxone

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23
Q

Calcium channel blocker overdose

A

Glucagon

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24
Q

Valproic acid

A

Carnitine

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25
Q

Aspirin (Salicylate)overdose

A

Sodium bicarbonate

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26
Q

Wernicke’s encephalopathy

A

Thiamine

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27
Q

Korsakoff’s

A

Thiamine

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28
Q

Methanol

A

Ethanol

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29
Q

Ethylene glycol

A

Fomepizole

Ethanol

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30
Q

Fomepizole

A

Competitive inhibitor of alcohol dehydrogenase

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31
Q

Methotrexate

A

Leucovorin

Folinic Acid

32
Q

Alcohol dehydrogenase

A

Catalyzes oxidation of ethanol to acetaldehyde

33
Q

Malignant hyperthermia

A

Dantrolene

34
Q

Cyclophosphamide ifosfamide side effect

A

Hemorrhagic cystitis

35
Q

Cyclophosphamide ifosfamide metabolite

36
Q

Cyclophosphamide toxicity

A

MESNA
Mercaptoethane
sulfonate

37
Q

Doxurubicin

Daunorubicin

A

Cardiotoxicity

38
Q

Doxurubicin antidote

A

Dexrazoxane

39
Q

Most cardiotoxic local anesthetic

A

Bupivacaine

40
Q

Theophylline Caffeine

41
Q

Atropine

A

Physostigmine

42
Q

Magnesium sulfate toxicity happens in

43
Q

Magnesium sulfate symptoms

A

BURP

decrease BP
decrease Urine output
decrease Respiratory rate
Absent patellar ref

44
Q

Magnesium sulfate toxicity

A

Calcium gluconate

45
Q

Anaphylactic shock

A

Epinephrine 0.5-1 ml

1:1000 dilution SQ

46
Q

Triad of Opiod Overdose

A

Respiratory failure
Miosis
Coma

47
Q

British Anti Louisite moa

A

Neutralizes heavy metals and promotes its elimination

48
Q

EDTA (Ethylene Diamine Tetraacetic Acid) MOA

A

chelates Ca and metal ions

49
Q

Organophosphate Poisoning sx

A 
Hypersecretion
Hypermotility
Bradycardia
Miosis
DUMBBELS
50
Q

Isoniazid Metabolite

A

Acetylhydrazine

51
Q

Acetaminophen toxic dose

52
Q

Acetaminophen toxicity causes depletion of

A

glutathione

53
Q

Acetaminophen metabolite

A

NAPQB1

N acetyl P benzoquinoneimine

54
Q

Chloroform toxicity (pathologic finding)

A

Centrilobular hepatic necrosis

55
Q

Acetylcysteine MOA

A

regenerates Glutathione

56
Q

DOG for Acromegaly

57
Q

Aspirin (Salicylate) Toxicity Sx

A

Initial Respiratory Alkalosis (Hyperventilation)

Anion Gap Metabolic Acidosis

Tinnitus

Hyperthermia

58
Q

Aspirin Toxic Dose

59
Q

Methanol Toxic dose

60
Q

Methanol overdose sx

A

CNS Depression
Wide anion gap acidosis
Optic disc hyperemia
Blindness

61
Q

Methanol Overdose Eye Pathologic Symptom

A

Snowstorm Vision

62
Q

Mediates doxurubicin daunorubicin toxicity

A

Topoisomerase IIB

63
Q

Side effect of methamphetamine

A

Dilated cardiomyopathy

64
Q

Drug of Choice for Intraoperative Arrhythmia

65
Q

Metabolite of catecholamine

A

Vallenylmandelic acid

66
Q

Metabolite of serotonin

A

5 hydroxyindole acetic acid

67
Q

Drugs that induce abnormal RBC production (DNA synthesis) 3

A

Methotrexate
Pyrimethamine
Trimethoprime

68
Q

12 - 24h after iron supplement, it is expected that

A

Intracellular iron enzyme replaced

Inc appetite

69
Q

36-48h iron supplement, it is expected that

A

Initial B response

Erythroid hyperplasia

70
Q

48 - 72h post intake of iron

A

Reticulocytosis peaking 5-7 days

71
Q

4-30 days post iron intake

A

Inc Hgb level

72
Q

1-3 mo post iron intake

A

Repletion of store

73
Q

Major thalassemia drug

A

5-Azacytidine

74
Q

Drugs that induce hemolysis (4)

A

Aspirin
Rasburicase
Sulfonamide
Primaquine (antimalarial)

75
Q

Severe digitalis toxicity

A

Digibind fab frag

76
Q

Group 1A anti arrhythmic tox

A

sodium lactate, vasopressor

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