Anticholinergics Flashcards
MOA Anticholinergics
block parasympathetic effect
sympathetic effects
Anticholinergic for motion sickness
Scopolamine
Decreases vertigo, post op nausea
Crosses BBB
Scopolamine MOA
Inhibits Central M1 receptor
Scopolamine side effect
Xerostomia
tachycardia
BOV
delirium
Dicyclomine MOA
competitive M3 antagonist decreases smooth muscle contraction and secretion of gut
M3 competitive antagonist for IBS and diarrhea
Dicyclomine
Dicyclomine side effects
increased IOP
urinary retention
tachycardia
confusion
Antagonistic at all M receptors (1,2,3)
causes mydriasis, cyclopegia
Atropine
What plant does atropine come from
Atropa Bella donna
Deadly nightshade
Jimson weed
Prevents synechiae after surgery
Dilates retina
Atropine
Reverses lethal bradyarrhythmia M2 and AV block
Atropine
Atropine SE
inc IOP in closed angle glaucoma
Competitive non-selective antagonist at all M receptors decreases bronchospasm
Ipratropriun
Competitivr antagonist at M3 for relief of bronchospasm
Tiotropium
Ipratropium SE
Cough
Xerostomia