Anticholinergics Flashcards

1
Q

MOA Anticholinergics

A

block parasympathetic effect

sympathetic effects

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2
Q

Anticholinergic for motion sickness

A

Scopolamine

Decreases vertigo, post op nausea
Crosses BBB

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3
Q

Scopolamine MOA

A

Inhibits Central M1 receptor

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4
Q

Scopolamine side effect

A

Xerostomia

tachycardia
BOV
delirium

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5
Q

Dicyclomine MOA

A

competitive M3 antagonist decreases smooth muscle contraction and secretion of gut

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6
Q

M3 competitive antagonist for IBS and diarrhea

A

Dicyclomine

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7
Q

Dicyclomine side effects

A

increased IOP
urinary retention
tachycardia
confusion

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8
Q

Antagonistic at all M receptors (1,2,3)

causes mydriasis, cyclopegia

A

Atropine

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9
Q

What plant does atropine come from

A

Atropa Bella donna
Deadly nightshade
Jimson weed

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10
Q

Prevents synechiae after surgery

Dilates retina

A

Atropine

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11
Q

Reverses lethal bradyarrhythmia M2 and AV block

A

Atropine

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12
Q

Atropine SE

A

inc IOP in closed angle glaucoma

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13
Q

Competitive non-selective antagonist at all M receptors decreases bronchospasm

A

Ipratropriun

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14
Q

Competitivr antagonist at M3 for relief of bronchospasm

A

Tiotropium

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15
Q

Ipratropium SE

A

Cough

Xerostomia

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16
Q

Slightly M3 selective muscarinig antagonist for detrussor bladder relaxation, urge incontinence and post-operative spasm

A

Oxybutunin

17
Q

Oxybutynin SE

A

constipation
tachycardia
increased IOP
xerostomia

18
Q

Tolterodine

A

M3 muscarinis anta for urinary incontincr

19
Q

Regenerates Ache

Relieves skeletal ms end plate block

A

Pralidoxime

20
Q

Pralidoxime is for

A

Early stage 48h cholinesterase toxicity

21
Q

Benztropine

A

M1 muscarinic antagonist for tremor and cogwheel rigidity

22
Q

Trihexyphenydyl

A

M1 muscarinic antagonist for tremor, cogwheel rigidity and EPS symptoms for antipsychotic blocking dopaminergic action

23
Q

“Hot as a hare”

A

M3 blockade leading to hyperthermia

24
Q

“Dry as a cracker”

A

M3 inhibition leading to dry mouth and decreased salivation

25
Q

“Blind as a bat”

A

M3 inhibition leading to mydriasis and cyclopegia

26
Q

“High pressure as a kettle”

A

M3 inhibition leading to mydriasis and decreased outflow of aqueous humor
-> Acute angle closure glaucoma

27
Q

“Mad as a hatter”

A

M1 inhibition crossing the BBB leading to sedation, agitation, hallucination and coma in elderly