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Pharma > Cholinomimetics > Flashcards

Cholinomimetics Flashcards

1
Q

M1 receptor organs

A

Nerve, CNS

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2
Q

M2 receptor organs

A

Heart and smooth muscle

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3
Q

M3 receptor organs

A

Endothelium, bladder GI, eye

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4
Q

M1 receptor and 2nd messenger

A

Gq

IP3 DAG

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5
Q

M2 receptor and 2nd messenger

A

Gi

dec cAMP

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6
Q

M3 receptor and 2nd messenger

A

Gq IP3 DAG

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7
Q

Nicotinic receptor organs

A

NMJ, Skeletal ms, adrenal glands, autonomic ganglia

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8
Q

Direct acting acetylcholine receptor agonists (2)

A

Esters

Alkaloids

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9
Q

Indirect acting binding to acetylcholinesterase (2)

A

Reversible

Irreversible

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10
Q

Muscarinic agonist, negligible nicotinic effect

A

Bethanecol

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11
Q

Muscarinic agonist for all receptors for post op ileus and urinary retention

A

Bethanecol

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12
Q

Muscarinic and nicotinic agonist for glaucoma

A

Carbachol

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13
Q

Bethanecol and carbachol SE

A

bronchospasm

mydriasis

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14
Q

Partial muscarinic agonist for Glaucoma and Sjogrens

A

Pilocarpine

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15
Q

Direct acting muscarinic agonist For asthma testing

A

Methacoline

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16
Q

Methacoline SE

A

PUD, bronchospasm

17
Q

Agonist at Nn & Nm receptors activating sympathetic and parasympathetic effects

A

Nicotine

18
Q

Selective nicotinic partial agonist for smoking

A

Varenicline

19
Q

Acetylcholinesterase inhibitor with short duration of action for DX of myesthenic and cholinergic crisis

A

Endrophonium

20
Q

Other name endrophonium

A

Tensilon test

21
Q

Covalently bonds to acetylcholinesterase to hydrolyze and release Ach but with longer acting effect for myesthenia gravis

A

Neostigmine

22
Q

Acetylcholinesterase inhibitor also used for post operative neurogenic ileus, urinary retention and antagonist for NM blockade drugs

A

Neostigmine

23
Q

Longer acting 4-6h anticholinesterase for MG

A

Pyridostigmine

24
Q

Alkaloid anticholinesterase that can cross BBB

A

Physostigmine

25
Q

Why can physostigmine cross BBB and the 3 others can’t

A

It is a tertiary amine while

others are quarternary

26
Q

Anticholinesterase inhibitors that can enter CNS but also treats glaucoma

A

Echothiophate

27
Q

Causes excessive muscarinic and nicotinic sx

A

Organophosphates (malathione, parathion, sarin)

28
Q

Regenerates acetylcholineste at NMJ relieves peripheral sx of organophosphate tox but cannot cross BBB

A

Pralidoxime

29
Q

Organophosphate poisoning antidote that crosses BBB

A

Atropine

30
Q

Organophosphate toxicity (sx)

A

DUMBBELS

31
Q

Acetylcholinesterase inhibitors used for Alzheimer (3)

A

Donapezil
Rivastigmine
Galantamine

32
Q

Acetylcholinesterase given as patch for Alzheimers

A

Rivastigmine

Pharma (26 decks)

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