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Pharmacology > Toxicity > Flashcards

Toxicity Flashcards

1
Q

antidote for acetaminophen

A

N-acetylcysteine (replenishes glutathione)

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2
Q

antidote for organophosphates (irreversible ACh inhibition)

A

atropine (muscarinic antagonist) and pralidoxime (PAM)

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3
Q

antidote for amphetamines

A

acidify urine with NH4Cl

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4
Q

antidote for antimuscarinics/anticholinergics

A

physostigmine and control hyperthermia

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5
Q

antidote for benzodiazepines

A

flumazenil

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6
Q

antidote for beta blockers

A

glucagon

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7
Q

antidote for CO

A

100% hyperbaric O2

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8
Q

antidote for Cu, As, Au

A

penicillamine

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9
Q

antidote for cyanide

A

nitrite + thiosulfate, hydroxocobalamin

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10
Q

antidote for digitalis

A

anti-dig Fab fragments

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11
Q

antidote for heparin

A

protamine sulfate

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12
Q

antidote for Fe

A

deferoxamine

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13
Q

antidote for Pb

A

EDTA, dimercaprol, succimer, penicillamine

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14
Q

antidote for Hg, As, Au

A

dimercaprol, succimer

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15
Q

antidote for methanol, ethylene glycol

A

fomepizole > ethanol, dialysis

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16
Q

antidote for methemoglobin

A

methylene blue, vitamin C

17
Q

antidote for opioids

A

naloxone, naltrexone

18
Q

antidote for salicylates

A

alkalinize urine with NaHCO3, dialysis

19
Q

antidote for TCAs

A

plasma alkalinization with NaHCO3

20
Q

antidote for tPA, streptokinase, urokinase

A

aminocaproic acid

21
Q

antidote for warfarin

A

fresh frozen plasma followed by vitamin K

22
Q

CYP450 inducers

A
  • chronic alcohol
  • St. John’s wort
  • phenytoin
  • phenobarbital
  • nevirapine
  • rifampin
  • griseofulvin
  • carbamazepine

Chronic alcoholics Steal Phen-Phen and Never Refuse Greasy Carbs.

23
Q

CYP450 inhibitors

A
  • acute alcohol
  • ritonavir
  • amiodarone
  • cimetidine
  • ketoconazole
  • sulfonamides
  • INH
  • grapefruit juice
  • quinidine
  • macrolides

AA RACKS IN GQ Magazine.

24
Q

sulfa drugs (for allergy purposes)

A
  • acetazolamide, furosemide, thiazides
  • celecoxib
  • sulfonamide abx, sulfonylureas, sulfasalazine

Pharmacology (22 decks)

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