DM Drugs Rapid Review

Question 1

rapid insulin includes`

Answer 1

lispro, aspart, glulisine

Question 2

very long acting insulin includes

Answer 2

detemir, glargine, ultralente

Question 3

glargine usually:

Answer 3

precipitates in subQ tissue

Question 4

detemir binds:

Answer 4

albumin

Question 5

-glitazone drugs

Answer 5

increase insulin sensitivity via PPARy

Question 6

-glinide drugs

Answer 6

similar to sulfonylureas, but bind to different site on K+ channel (stimulate insulin release)

Question 7

-gliptin

Answer 7

DPP4 inh –> increased GLP-1

Question 8

-flozin

Answer 8

SGLT2 inb in PCT

Question 9

acarbose

Answer 9

inh of a-glucosidase in intestine

Question 10

miglitol

Answer 10

inh of a-glucosidase in intestine

Question 11

pramlintide

Answer 11

amylin analogue which slows gastric emptying and ultimately decreases glucagon

Question 12

exenatide

Answer 12

GLP-1 analogue

Question 13

liraglutide

Answer 13

GLP-1 analogue

Question 14

metformin

Answer 14

inhibits gluconeogenesis, increases glycolysis and insulin sensitivity, don’t give in renal pts due to risk of lactic acidosis

Question 15

chlorpropamide, tolbutamide, glimepiride, glipizide, glyburine

Answer 15

sulfonylureas