Tougher Stuff

Question 1

Peripheral rim staining pattern of immunoglobulins are found for which immunoglobin?

Answer 1

Anti-DNA

Question 2

Homogenous staining pattern of immunoglobulins are found for which three immunoglobins?

Answer 2

Anti-DNA
Anti-Histone
Anti-DNP

Question 3

Speckled staining pattern of immunoglobulins are found for which four immunoglobulins?

Answer 3

Anti-Sm
Anti RNP
anti-Ro and La
Anti-scl70

Question 4

Centromere staining pattern of immunoglobulins are found for which immunoglobin?

Answer 4

Anti-centromere

Question 5

Nucleolar pattern of immunoglobulins are found for which immunoglobin?

Answer 5

Anti-nucleolar

Question 6

What are the two morphological patterns seen in acute humoral rejection of the kidneys?

Answer 6

1. Necrotizing vasculitis

2. Intimal thickening d/t accumulation of fibroblasts

Question 7

What is the triad of features of ACUTE liver rejection?

Answer 7

1. Portal tract inflammation
2. Bile duct damage
3. Endotheliitis of portal vein and hepatic arteries

Question 8

What are the two major features of CHRONIC liver rejection?

Answer 8

1. Bile duct disappearance

2. portal/hepatic fibrosis

Question 9

What are the skin changes for acute and chronic GVHD?

Answer 9

Acute = rash/exfoliation
Chronic = N/A

Question 10

What are the GIT changes for acute and chronic GVHD?

Answer 10

Acute = Ulcerative gastroenteritis
Chronic = Strictures

Question 11

What are the Hepatic changes for acute and chronic GVHD?

Answer 11

Acute = bile duct necrosis
Chronic = Jaundice

Question 12

What is the difference between drug induced lupus and regular ol’ Lupus?

Answer 12

No renal or CNS pathology

Question 13

What are the chronic renal changes in systemic sclerosis?

Answer 13

Thickened interlobular arteries d/t collagen deposition

Question 14

Citrullinated peptides are seen in what disease?

Answer 14

RA

Question 15

What is the most common solid malignancy in childhood?

Answer 15

Neuroblastoma

Question 16

What is the most common solid malignancy in infants?

Answer 16

Sacrococcygeal teratoma

Question 17

What is the most common vascular tumor in infants?

Answer 17

Hemangioma

Question 18

What is the most common fibrous tumor in childhood?

Answer 18

Myofibromatosis

Question 19

Antibodies to dsDNA is specific for what disease?

Answer 19

SLE

Question 20

Antibodies to Histones are specific for what disease?

Answer 20

Drug induced SLE

Question 21

Antibodies to DNA topoisomerase I is specific for what disease?

Answer 21

Diffuse scleroderma

Question 22

Antibodies to centromeric proteins are are specific for what disease?

Answer 22

CREST syndrome

Question 23

Antibodies to SS-A (Ro) and SS-B (La) are specific for what disease?

Answer 23

Sjogren’s syndrome

Question 24

Anti Sm = what disease?

Answer 24

SLE

Question 25

What are the patterns that dsDNA can be found in?

Answer 25

Peripheral

Homogenous

Question 26

What are the patterns that anti-histones can be found in?

Answer 26

Homogenous

Question 27

What is the pattern that anti-scl-70 can be found in?

Answer 27

Speckled

Question 28

What is the pattern that Anti-ro and la can be found in?

Answer 28

Speckled

Question 29

What is the pattern that anti centromeres can be found in?

Answer 29

Centromere

Question 30

Anti-nucleolar pattern of staining indicates what two diseases?

Answer 30

SLE + PSS (mixed CT disease)