Topical Anesthetic Properties

Question 1

How do topical anesthetics work?

Answer 1

Block influx of NA+ ions so that the nerve can’t be depolarized

Question 2

What are the 3 parts of the structure of topical anesthetics?

Answer 2

Aromatic residue (lipophilic)
Intermediate chain (increased length = increased potency)
Amino group (hydrophilic)

Question 3

Which has a longer duration of action, amides, or esters?

Answer 3

Amides

Question 4

Amides are less toxic, why?

Answer 4

Metabolized by the liver

Question 5

Where are esters metabolized?

Answer 5

Locally

Question 6

All topical anesthetics are made from what base?

Answer 6

Ester