General Pharm Outline Flashcards
What 3 factors affect absorption?
First-pass metabolism
Blood flow at administration site
Demographic factors
What is the volume of distribution equation?
Amount of drug in the body/concentration of drug in the plasma
What is the clearance equation?
Volume/time
How do zero order kinetics work?
A constant amount of drug is being eliminated per unit time
How do first oder kinetics work?
A constant fraction of drug is eliminated per unit time
Half-life rules apply to which type of kinetics?
First order
How many half lives does it take to remove a drug from the body under first order kinetics?
About 3-5
What is potency of a drug?
The amount of drug required to achieve the therapeutic effect. Lower dose needed=more potency
What is the affinity of a drug?
Potential for drug-receptor binding
What is the only available form of bacitracin?
Ointment
What gram coverage does Bacitracin offer?
(+) Only
What gram coverage does amoxicillin offer?
Both
What gram coverage does dicloxacillin offer?
(+)
What gram coverage do cephalosporins offer?
(+)
As cephalosporins increase in generation, they gain what gram coverage?
More (-) to go with the (+)
