Cholinergic Agonists Flashcards
What are the three main structures in the eye that receive parasympathetic innervation?
Iris sphincter
Ciliary muscle
Lacrimal gland
Name two conditions that cholinergic agonists may be used to treat.
Glaucoma
Accommodative esotropia
What is the most common ocular cholinergic agonist?
Pilocarpine
How does an anticholinesterase agent work?
They are indirect cholinergic agonists
What are the 4 indirect cholinergic agonists?
Neostigmine
Edrophonium
Echothiophate
Pyridostigmine
Mainly, the indirect cholinergic agonists are used to treat what?
Myasthenia gravis
Which Anticholinesterase agent isn’t used for myasthenia gravis?
Echothiophate
What is the MOA of pilocarpine?
Stimulates the longitudinal muscle of the ciliary body, which pulls posteriorly on the scleral spur, and secondarily opens up the TM to increase outflow of aqueous humor
What drug is used to prep for an LPI and why?
Pilocarpine
Pulls the iris taut
What are the 3 most common side effects of pilocarpine?
Browaches
Headaches
Myopic shifts
What are the 3 less common side effects of pilocarpine?
Cataracts (long-term use)
RD (uncommon, but recognized)
Secondary angle closure glaucoma
How do anticholinesterase agents work?
Direct agonists by inhibiting acetylcholinesterase
What are the direct cholinergic agonists (4)?
Pilocarpine
Acetylcholine
Bethanechol
Carbachol
What are the indirect cholinergic agonists?
Edrophonium
Echothiophate
Pyridostigmine
Neostigmine
What are the indirect cholinergic agonists used for?
Myasthenia gravis
