Topical -Active Flashcards
What is the main diffusion barrier of the skin
Stratum corneum
3 main routes for entry into the skin
Intracellular
Intercellular
Transappendegeal
Difference between absorption and penetration
Absorption gets all the way to the bottom layer of the skin and sucked into the blood stream
What does skin entry depend on x4
The base
Variations in skin
Physical and chemical properties of the active ingredient
The concentration of the active ingredient
Properties of active ingredient that enhance penetration x3
Low molecular weight
Lipophilic
Non polar
Where is caution taken with topical medication x4
Pregnancy
Infancy or neonates
Inflammatory conditions
Systemic Absorption
Why is there systemic toxicity from topical medication in neonates x5
- Decreased hepatic metabolism
- Decreased renal excretion
- Increased surface area to body ration
- Suboptimal epidermal barrier function
- Decreased plasma protein binding
Name any 5 active ingredients
Antifungals
Scabicides
Keratolytics
Sunscreen
Corticosteroids
MOA of hydrocortisone x3
Suppression of inflammation
Reduction in cell proliferation
Vasoconstriction
Conditions least responsive to topical corticosteroids x4
Keloids
Hypertrophic scar
Alopecia areata
Acne cysts
Side effects of corticosteroids x5
Atrophy
Striae
Bruising
Telangiectasia
Hypertrichosis
Suppression of pigmentation
Effects of using corticosteroids on the face and around the eyes x2
Perioral dermatitis
Glaucoma
Features of iatrogenic cushing syndrome x5
Central obesity
Muscle weakness
Hirsutism
Acne
High BP
Where to avoid use of potent corticosteroids x3
Babies
Face
Genital area
Grams limit of potent and intermediate steroids for adults x2
Potent <10g/week
Intermediate <100g/week
