Autoimmune

Question 1

Multisystem autoimmune diseases x2

Answer 1

SLE
Systemic sclerosis

Question 2

Skin targeting autoimmune disease x3

Answer 2

Localized scleroderma ie morphea
Chronic autoimmune urticaria
Autoimmune bullous diseases

Question 3

Complex skin conditions in which autoimmunity is a major factor x2

Answer 3

Vitiligo
Psoriasis

Question 4

Types of lupus erythematosus x4

Answer 4

Acute and subacute cutaneous erythematosus
Tumid LE
Chronic discoid LE

Question 5

Define blister and types of fluid x3

Answer 5

Fluid filled collection within the skin
Clear, straw colored, bloody

Question 6

Differential diagnosis for intraepidermal blister x3

Answer 6

Pemphigus
Herpes simplex
Acute dermatitis

Question 7

Differential diagnosis for sub epidermal blister x3

Answer 7

Pemphigoid
Blistering porphyrias
Dermatitis herpetiformis

Question 8

Infectious causes of blisters x5

Answer 8

VZV
HZ
Coxsackie virus
Staph aureus
Strep pyogenes

Question 9

Presenting feature of bullous pemphigoid

Answer 9

Itchy erythematous plaques and papules

Question 10

Immunofluorescence results for pemphigoid

Answer 10

Linear IgG and complement deposits around the basement membrane

Question 11

Pathogenesis of pemphigoid x3

Answer 11

Circulating IgG antibodies react with antigens ie BPAG1 and 2 in BM> local complement activation and tissue damage > sub epidermal bulla

Question 12

Localized and generalized treatment of pemphigoid x5

Answer 12

Local- topical corticosteroids
General- oral corticosteroids
Azathioprine
Tetracycline
Dapsone

Question 13

Name a linear IgA dermatoses

Answer 13

Chronic bullous dermatoses of childhood

Question 14

Sites of erosions in pemphigus x6

Answer 14

Rectum
Vulva
Pharynx, Larynx
Esophagus
Conjunctivae

Question 15

Pathogenesis of pemphigus

Answer 15

Destruction of intracellular adhesions substances by IgG antibodies

Question 16

Define acantholysis

Answer 16

Loss of intracellular adhesion sites

Question 17

Sites of dermatitis herpetiformis x5

Answer 17

Face and Scalp
Buttocks
Extensor surface of knees and elbows

Question 18

Describe dermatitis herpetiformis

Answer 18

Gluten sensitive autoimmune disease that causes small grouped blisters on erythematous edematous base

Question 19

What does coeliac serology show for DH

Answer 19

IgA antibodies to tissue transglutaminase

Question 20

What does histology show for DH x3

Answer 20

Sub epidermal blister
Predominate neutrophils
Micro abscess in dermal papillae

Question 21

Treatment of DH x3

Answer 21

Dapsone
Tetracycline
Sulphapyridine

Question 22

Complication of DH

Answer 22

Small bowel lymphoma

Question 23

Pathogenesis of scleroderma x3

Answer 23

Autoimmune inflammatory disease of the dermis> abnormal collagen turnover > skin tightening and hardness