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Dermatology > Autoimmune > Flashcards

Autoimmune Flashcards

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Dermatology Board Prep flashcards
1
Q

Multisystem autoimmune diseases x2

A

SLE
Systemic sclerosis

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2
Q

Skin targeting autoimmune disease x3

A

Localized scleroderma ie morphea
Chronic autoimmune urticaria
Autoimmune bullous diseases

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3
Q

Complex skin conditions in which autoimmunity is a major factor x2

A

Vitiligo
Psoriasis

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4
Q

Types of lupus erythematosus x4

A

Acute and subacute cutaneous erythematosus
Tumid LE
Chronic discoid LE

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5
Q

Define blister and types of fluid x3

A

Fluid filled collection within the skin
Clear, straw colored, bloody

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6
Q

Differential diagnosis for intraepidermal blister x3

A

Pemphigus
Herpes simplex
Acute dermatitis

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7
Q

Differential diagnosis for sub epidermal blister x3

A

Pemphigoid
Blistering porphyrias
Dermatitis herpetiformis

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8
Q

Infectious causes of blisters x5

A

VZV
HZ
Coxsackie virus
Staph aureus
Strep pyogenes

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9
Q

Presenting feature of bullous pemphigoid

A

Itchy erythematous plaques and papules

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10
Q

Immunofluorescence results for pemphigoid

A

Linear IgG and complement deposits around the basement membrane

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11
Q

Pathogenesis of pemphigoid x3

A

Circulating IgG antibodies react with antigens ie BPAG1 and 2 in BM> local complement activation and tissue damage > sub epidermal bulla

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12
Q

Localized and generalized treatment of pemphigoid x5

A

Local- topical corticosteroids
General- oral corticosteroids
Azathioprine
Tetracycline
Dapsone

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13
Q

Name a linear IgA dermatoses

A

Chronic bullous dermatoses of childhood

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14
Q

Sites of erosions in pemphigus x6

A

Rectum
Vulva
Pharynx, Larynx
Esophagus
Conjunctivae

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15
Q

Pathogenesis of pemphigus

A

Destruction of intracellular adhesions substances by IgG antibodies

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16
Q

Define acantholysis

A

Loss of intracellular adhesion sites

17
Q

Sites of dermatitis herpetiformis x5

A

Face and Scalp
Buttocks
Extensor surface of knees and elbows

18
Q

Describe dermatitis herpetiformis

A

Gluten sensitive autoimmune disease that causes small grouped blisters on erythematous edematous base

19
Q

What does coeliac serology show for DH

A

IgA antibodies to tissue transglutaminase

20
Q

What does histology show for DH x3

A

Sub epidermal blister
Predominate neutrophils
Micro abscess in dermal papillae

21
Q

Treatment of DH x3

A

Dapsone
Tetracycline
Sulphapyridine

22
Q

Complication of DH

A

Small bowel lymphoma

23
Q

Pathogenesis of scleroderma x3

A

Autoimmune inflammatory disease of the dermis> abnormal collagen turnover > skin tightening and hardness

Dermatology (12 decks)

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