Topic list C

Question 1

Bactericidal examples

Answer 1

Rifampin - inhibits RNA pol
Metronidazol - destroys DNA and RNA in anaerobes
Fluoroquinolones - inhibit DNA gyrase and topoisomerase
Aminoglycosides - 30s inhibitors
Beta-Lactams - inhibit transpeptidase.
Polypeptide antibiotics, Colistin, Polymyxin B. - porate gram negatives, only for topical use.

Question 2

Bacteriostatic examples

Answer 2

All the 50S inhibitors: (except for the streptogramin-kristin the killer)
Macrolides, Lincosamides, Chloramphenical, Linezolid,

Tetracyclines.

Question 3

What are essential times to give bactericidal and not static drugs

Answer 3

Severe infections such as:
Endocarditis
Meningitis
All infections in immunocompromised people.

Question 4

Types of antibiotic therapy:

Answer 4

Empiric: when theres no time, in critically ill patients, must give strong broad ab’s to manage the infection.
Empiric combination therapy should not be administered for morethan 3–5 days. De-escalation to the most appropriate single therapy should be performed as soon as the susceptibility profile is
known,

Sensitivity based: on screening of the susceptibility

Prophylactic