Chloramphenicol, polymyxin

Question 1

Chloramphenicol MoA

Answer 1

binds 50S subunit inhibits protein synth

Question 2

Chloramphenicol spectrum and indications

Answer 2

The first really broad spectrum

Severe SEs limits its use currently to:
Brain abscesses
Mixed resistant infections
Meningitis
Ricketsioisis in children

Question 3

Chloramphinicol SEs

Answer 3

Gray baby syndrome
inadequate glucuronidation/elimination of the drug causes accumulation, interferes with mitochondrial human ribosomes.
Respiratory depression, hypoxia death

Dose dependent aplastic anemia
Hemolytic anemia in G6PDH def.

Interactions: Inhibits CYP. Increasing Warfarin and phenytoin concentrations.

Question 4

Polymyxin - what are the drugs

Answer 4

A MIX of POLYpeptides

Polymyxin B -
Polymyxin E - colistin

Question 5

Polymyxin MoA

Answer 5

binds membrane polypeptides creating pores

Question 6

Polymyxin spectrum and indications

Answer 6

Against most G-neg bact.

Uses: Against P. aeruginosa or other significant pulmonary infections. Esp in Cystic fibrosis.

Question 7

Polymyxin SEs

Answer 7

Nephrotoxicity

Neurotoxicity