B16 synthetic and semisynthetic opiates Flashcards
1
Q
What is a semisynthetic opioid?
List them
A
A structural derivative of the 3 natural opiates: morphine, codeine, and thebaine.
Morphine derivatives:
- Dihydromorphone, Hydromorphone, Dilaudid
- Heroin, Diacetylmorphine
- Ethylmorphine - decreased potency, similar to codeine
- Oxymorphone - increased potency
- Nalorphine - mu antagonist, very strong K-agonist not used.
- Naltrexone - oral antagonist. (competivitve)
- Naloxone - iv antagonist
Codeine derivatives:
- Dihydrocodeine
- Dihydrocodone
- Oxycodone
Thebaine derivatives;
- Buprenorphine
- Nalbuphine
2
Q
What are the synthetic opioids
A
Fentanyl, Sufentanil, Alfentanil, Remifentanil Meperidine Methadone Tapentadol Tramadol
Pentazocine
Butrophanol
Pentazocine
Dextromethorphan
Loperamide
Diphenoxalate
3
Q
Hydromorphone and Hydrocodone relative potency to morphine
A
Dilaudid ~10 times more potent.
