Topic list A random notes

Question 1

omega-Conotoxin

Answer 1

Blocks calcium channels, non-specific presynaptic inhibition.

Question 2

Bretylium

Answer 2

Inhibits presynaptic NE release, also blocks K+ channels on the heart as an antiarrhythmic

Question 3

Guanethidine

Answer 3

Inhibits presynaptic NE release

Antihypertensive with strong side effects

Question 4

Debrisoquine

Answer 4

Same as quanethidine

Guanethidine and Debrisoquine

Both inhibit NE release and are rarely used antihypertensives

strong orthostatic hypotens. Impaired ejaculation, diarrhea.

Question 5

Fenoldopam

Answer 5

D1 agonist, stays peripheral.

Dilates mesenteric beds.

Question 6

Guanfacine and Guanabenz

Answer 6

alpha2 agonists like clonidine but with different structures.
Guanafacine, for ADHD
guanabenz for HTX

Question 7

Xylometazoline
and
oxymetazoline

Answer 7

Non-­selective
α
receptor
agonists

topical decongestants.

Question 8

Drugs
acting
on
the
imidazoline
receptors

Answer 8

Clonidine binds alpha2 and imidazoline I1 receptors

Moxonidine
and
Rilmenidine
are imidazoline agonists

Used for hypertension

Question 9

Non-­‐selective
α
receptor
antagonists

Answer 9

 Phenoxybenzamine
 Phentolamine
 Tolazoline

Question 10

Baclofen

Answer 10

GABAb agonist

central muscle relaxant/spasmolytic

Question 11

Rilozole

Answer 11

inhibition of CNS glutamate transmission.
Central muscle relaxant.

Used for ALX

Question 12

Sugammadex

Answer 12

Binds Rocuronium and Vecuronium, to stop non-depolarizing muscle blockade.

Question 13

Atracurium and histamine

Answer 13

Atracurium can cause histamine release, and a large drop in blood pressure, flushin, and brochospasm.