Pharmacokinetics lecture

Question 1

Heparin Vd

Answer 1

0.06 L/Kg

Approximates plasma

Question 2

Insulin Vd

Answer 2

0.08 L/Kg

Question 3

Acetominophen/Paracetamol Vd

Answer 3

1 L/kg

Question 4

Ampicillin Vd

Answer 4

0.3 l/kg

Question 5

Propranalol Vd

Answer 5

3.0 l/kg

Question 6

Digoxin Vd

Answer 6

7 l/kg

very high distribution into the muscles and binding tissue proteins.

Question 7

Imipramin Vd

Answer 7

15 l/kg

Question 8

Gentamycin Vd

Answer 8

0.2 l/kg

aminoglycosides approximate the Extracellular fluid compartment.
Small, so they move through cappillary slits, but charged, so the do not enter cells.

Question 9

Ethanol

Answer 9

0.6 l/kg

Approximates total body water, low molecular weight and lipophilic.

Question 10

What drugs have zero order kinetics?

Answer 10

Ethanol
Aspirin
Phenytoin

Generally, drugs that have very large doses, which saturate the elimination mechanisms.

Question 11

How does the Vd of a drug affect its level of fluctuation around its steady state concentration?

Answer 11

Larger Vd causes larger fluctuations of concentration. after each dose