Carbapenems Monobactams Beta lactamase inhibs

Question 1

Carbapenem drugs
1st gen
2nd gen

Answer 1

1st Ertapenem

2nd Imipenem, meropenem, doripenem

Question 2

Carbapenems spectrum

Answer 2

Broad, G+ and G-
includes pseudomonas and acinetobacter
Klebsiella and acinetobacter are emerging resistances, expressing Metallo-Beta-Lactamases MBLs
in this case you need to use Monobactams

Question 3

Carbapenems Kintetics

Answer 3

Good penetration, enters CNS.
Not enter bile tract

Long post antibiotic effect.

Eleminated by kidney. Imipenem is administered with cilastatin, a dihydropeptidase inhibitor to prevent kidney inactivation.

Question 4

Crabapenems indications

Answer 4

Ertapenem: Severe community ammonia, intraabdominal infections

Imipenem, Doripenem:
Acinetobacter, Enterobacter infections

Severe polymicrobial infections and nosocomial infections in empiric therapy.

Meningitis for resistant pathogens

Question 5

Carbapenem adverse effects

Answer 5

GI - dysbacteriosis

Allergies.

Question 6

Monobactam drug

Answer 6

Aztreonam

Question 7

Monobactam kinetics, indication and spectrum

Answer 7

Only administered IV.

Good distribution, enters CNS.

Only treats G-negative bacteria.

Indications: Nosocomial, resistant G- infections.

Question 8

Beta lactamase inhibitors: list the 3 and their associated penicillin

Answer 8

Clavulinic acid and amoxicillin

Sulbactam and ampicillin

Tazobactam and piperacillin