Tetracyclins Flashcards
Short acting tetracylines
Tetracyclin
Oxytetracyclin
Long acting tetracyclines
Doxycycline
Minocycline
Tetracyclin MoA
Reversibly Inhibits 30S subunit
Spectrum
broad spect
static or cidal
Bacteriostatic
Pharmacokinetics
Good absorption,
They are Chelated, and dairy products decrease their absorption
Concentrate in the bile, liver, kidney, gingiva, and skin.
Also binds to and concentrates tissues or tumors that are undergoing calcification
Crosses placental barrier and CNS
Tetracyclin indications
Pneumococcus and streptococcus
E. coli, H. influenzae
Spirochetes other than treponema -
Lymes/Borreliosis, Leptospirosis, Rickettsia
Intracellular pathogens:
Chlamydia, Mycoplasma
Brucella, Tularemia
Chronic bronchitis exacerbations
Prostatitis
Tetracyclin Adverse Effects
Chelate formation - tooth discoloration in adolescents
GI disturbances
Photosensitivity
Hepatotoxicity
Nephrotoxicity
Glycylcyclines: drug name
Tigacycline
Glycylcyclines spectrum and indications
Resistant staph and strep infections
MRSA, VRE
Enterobacteriaciae
Ricketssia Chlamydia Legionella
NOT-effective against psuedomonas
Indications:
complicated skin or tissue infections
complicated intra-abdominal infections
TIgacycline pharmacokinetics
Only IV admin
Long half life, 40 hrs.
Excreted by bile (not effective for UTIs)
Glycylcyclines adverse effects
Nausea, vomitting
Acute pancreatitis that is possibly fatal
Liver damage, elevated liver enzymes
Nephrotoxicity
