Topic 8

Question 1

During which part of the cell cycle are gene mutations most likely to occur?

Answer 1

Interphase

Question 2

Explain how the methylation of tumour suppressor genes can lead to cancer (3)

Answer 2

1. Methylation prevents transcription of gene;
2. Protein not produced that prevents cell division / causes cell death / apoptosis;
3. No control of mitosis.

Question 3

Explain the effects of oestrogen on gene transcription and its role in hormone sensitive cells