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4 Craniofacial biology > Tooth Development 1 > Flashcards

Tooth Development 1 Flashcards

1
Q

what is odontogenesis?

A

process of tooth development

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2
Q

what is histogenesis?

A

differentiation of cells to make new tissues

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3
Q

name the mineralised dental tissues

A

enamel, dentine and cementum

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4
Q

name this unmineralised dental tissues?

A

dental pulp and periodontium

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5
Q

what does the vestibular lamina do?

A

contributes to the vestibule of the mouth and delineates the lips and cheek from the teeth formation of sulcus

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6
Q

describe the outer enamel epithelium

A

outer layer of cuboidal cells that limits the enamel organ

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7
Q

describe the stellate reticulum

A

group of cells in the enamel organ
Epithelial origin but some mesenchymal characteristics e.g. collagen I,II&III synthesis

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8
Q

describe the stratum intermedium

A

two/three layers of cells that sit above the inner enamel epithelium

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9
Q

describe the inner enamel epithelium

A

columnar shaped cells rich in RNA connected together by desmosomes

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10
Q

what does the dental lamina do?

A

define where the tooth germ will be

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11
Q

name the stages in tooth development

A

initiation stage
bud stage
cap stage
bell stage
crown stage (also called last bell stage)

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12
Q

preparation before teeth can be formed

? has ? migrating into it -> week ?

Condensation of ectomesenchyme in response to ?

primary ? band being formed

Gives rise to ?? and ??

A

mesenchyme
ectomesenchyme
6

FGF8

epithelial

dental lamina
vestibular lamina

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13
Q

preparation before teeth can be formed

Formation of the ? (vestibule) weeks ?

?? grows into ? weeks ? and ?

Then ? -> weeks ?

Forms ? between the teeth and ??

A

sulcus
7-12

vestibular lamina
mesenchyme
7
8

breaks down
11-12

vestibule
cheeks/lips

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14
Q

tooth development involves an interaction between what?

A

epithelium - ectoderm
mesenchym - ectomesenchyme

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15
Q

in tooth development what does the epithelium (Ectoderm) give rise to?

A

enamel and hyaline layer of the root

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16
Q

in tooth development what does the mesenchyme (Ectomesenchyme) give rise to?

A

dentine, pulp, cementum and periodontium (PDL and bone)

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17
Q

what initiates tooth development?

A

epithelium

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18
Q
A

dental lamina

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19
Q
A

primary epithelial band

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20
Q
A

vestibular lamina

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21
Q

what week is this?

A

week 7

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22
Q

what week is this?

A

week 8

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23
Q

whats happening here?

A

cell death

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24
Q

what week is this?

A

week 11

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25
Q

what week is this?

A

week 12

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26
Q
A

enamel organ

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27
Q
A

dental papilla

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28
Q
A

dental lamina

29
Q

when is the initiation stage?

30
Q

when is the bud stage?

31
Q

what happens in the bud stage?

A

initiation of epithelial proliferation into the mesenchyme causing the mesenchyme to condense into a ball (bud)

32
Q

when is the cap stage?

33
Q

what happens in the cap stage?

A

epithelial migration and proliferation within the mesenchyme to surround the condensed ectomesenchyme

34
Q

when is the bell stage?

35
Q

what happens in the bell stage? 4

A

dental lamina shrinks and degrades

inner ectomesenchyme -> dental papilla

outer ectomesenchyme -> dental follicle

enamel organ has 4 distinct layers

36
Q

when is the dental lamina removed from the source?
what does this leave behind?

A

week 17

Cell nests and cell rests which have cystic potential

37
Q

what happens in the crown stage?

A

Hard tissue formation -> dentine and enamel

38
Q

what are the 4 layers of the enamel organ from outer to innermost

A

outer enamel epithelium
stellate reticulum
stratum intermedium
inner enamel epithelium

39
Q
A

stellate reticulum

40
Q
A

stratum intermedium

41
Q
A

dental follicle

42
Q
A

inner enamel epithelium

43
Q
A

outer enamel epithelium

44
Q
A

dental lamina

45
Q
A

dental papilla

46
Q

Inner enamel epithelium

forms ?? which will conform to ?

? cells at cusp tips that form ?

A

basal lamina
ADJ

columnar
ameloblasts -> enamel

47
Q

what does the stratum intermedium do?

A

Synthesis and transport stuff for the inner enamel epithelium e.g. matrix growth factors

48
Q

Stellate reticulum

? shaped due to ?

Role in ?

A

star
desmosomes

maintenance of shape and protection

49
Q

Outer enamel epithelium

? cells

Role to

A

cuboidal

maintain shape and allow exchange between ectomesenchyme and enamel organ

50
Q

what stage of tooth germ is this?

51
Q

What stage is this?

52
Q
53
Q
A

bell stage

54
Q
A

late bell stage

55
Q
A

crown stage

56
Q
A

crown stage

57
Q
A

crown stage

58
Q

what is this?

A

Enamel knot

Area of developing enamel that is a signal centre

59
Q

what is this?

A

Enamel niche

When dental lamina breaks down seen as a hole or depression

60
Q

what is this?

A

Enamel septum

Forms between the outer and inner epithelial cells, aids the change in shape from cap to bell stage

61
Q

what controls the initiation stage of tooth development?

A

epithelial signalling of growth factors that act on mesenchyme

SHH, BMP4 and FGF8

62
Q

what controls the bud stage of tooth development?

A

mesenchymal signalling of growth factors that act on epithelium

Msx1, Pax9 and Bmp4

63
Q

what controls the cap stage of tooth development?

A

enamel knot signalling that acts on mesenchyme and epithelium

FGF4/9 and BMP4/2

64
Q

what does the extracellular matrix do in tooth development?

A

Allows growth factors to bind, switch on and release

Allows cell adhesion, proliferation, migration, polarisation and differentiation

65
Q

name some important matrix molecules

A

Type I, III, IV collagen, laminin and other proteoglycans - syndecan and tenascin

66
Q

why are these matrix molecules important?
Type I, III, IV collagen, laminin and other proteoglycans - syndecan and tenascin

A

they ensure an intact membrane which is needed for mesenchyme and odontoblasts to bind to it so they can differentiate

67
Q

name a cytokine important in tooth development

68
Q

understand this overview

4 Craniofacial biology (20 decks)

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