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4 Craniofacial biology > Overview and Summary of Tooth Development > Flashcards

Overview and Summary of Tooth Development Flashcards

1
Q

what is the scientific name for tooth development?

A

odontogenesis

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2
Q

when does odontogenesis start?

A

6 weeks

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3
Q

what structure initiates tooth development?

A

epithelium
Then interaction between ectomesenchyme and epithelium

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4
Q

remember
For tooth development to occur need both the epithelium and ectomesenchyme

A
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5
Q

Need ? and ? to switch genes on for tooth development

A

msx1 and 2

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6
Q

what stage of tooth development?

A

bud stage

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7
Q

what stage of tooth development?

A

cap stage

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8
Q
A

cap stage

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9
Q
A

bell stage

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10
Q
A

crown stage

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11
Q
A

crown stage

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12
Q
A

crown stage

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13
Q
A

late bell stage

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14
Q

when is the bud stage?

A

week 8

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15
Q

when is the cap stage?

A

week 11

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16
Q

when is the bell stage?

A

week 14

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17
Q
A

enamel organ

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18
Q
A

dental papilla

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19
Q
A

dental lamina

20
Q

remember

21
Q

remember

22
Q
A

dental follicle

23
Q
A

enamel organ

24
Q
A

outer enamel epithelium

25
Q
A

stellate reticulum

26
Q
A

stratum intermedium

27
Q
A

inner enamel epithelium

28
Q
A

dental papilla

29
Q
A

odontoblasts

30
Q
A

predentine

31
Q
A

ameloblasts

32
Q

where in the developing tooth is the dentine first layed down?

A

cusps
as closer to enamel knot so more growth factors etc.

33
Q

where does signalling come from for initiation?

A

epithelium

34
Q

what genes are in initiation?

A

BMP
FGF/EGF?
MSX
Shh

35
Q

where does signalling come from for the bud stage?

A

ectomesenchyme

36
Q

signalling from the ectomesenchyme in the bud stage results in what?

A

proliferation/condensation

37
Q

what genes are involved in the bud stage?

A

BMP 2-4
DIX
Syndecan
Tenascin

38
Q

where does signalling come from for the cap stage?

A

enamel knot (epithelium)

39
Q

signalling from the enamel knot in the cap stage results in what?

A

proliferation, differentiation and morphogenesis

40
Q

what genes are involved in the cap stage?

A

collagen
dix 1-3

41
Q

what determines which teeth will develop where? (general)

A

transcription factors

42
Q

which transcription factors determine which tooth will develop where? 5

A

MSX-1, MSX-2, DIX1/2, Barx-1, Alx-3

43
Q

teeth only form in specific areas due to transcription factors. name 3?

A

pitx2
shh
wnt

44
Q

what does Shh do?

A

increase cell proliferation
only in dental epithelium

45
Q

what does wnt do?

A

arrests tooth development

4 Craniofacial biology (20 decks)

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