Collagen disorders

Question 1

what is the function of collagen?

Answer 1

provides rigidity, elasticity and strength -> maintains structural integrity of tissues

Question 2

what is the structure of collagen?

Answer 2

triple helix

Question 3

Synthesis of collagen

mRNA goes from nucleus to ??? where ??? is produced

It is modified in the ? of ??? through ? and ?

?? molecules form a ? molecule

Enter the ?? and modified through addition of ?

Procollagen enters ?? where peptidase ? propeptides forming a ? molecule called ?

This ? self assembles into a regularly staggered array forming ?

The fibrillar structure is maintained through ? bonds between the lysine and hydroxylysine of neighbouring ? molecules

Cross linking of tropocollagen leads to the formation of ?, which is catalysed by ?

Answer 3

RER
preprocollagen alpha chain

cisternae
RER
hydroxylation
glycosylation

3 preprocollagen
procollagen

golgi apparatus
oligosaccharides

extracellular matrix
cleaves
shorter
tropocollagen

spontaneously
fibrils

covalent
tropocollagen

collagen fibres
lysyl oxidase

Question 4

collagen maintains the firmness and elasticity of skin. what types of collagen are present in the skin?

Answer 4

1 and 3

Question 5

collagen is important in the formation of scars in wound healing. what types of collagen increase in abundance during wound healing?

Answer 5

1 and 3

Question 6

collagen lubricates the ends of bones to allow movement. what type of collagen is here?

Answer 6

type 1

Question 7

remember
collagen is in Cartilage, tendon, ligament -> withstand and emit large forces between ligament and bone
Muscles

Question 8

what type of collagen is in the basal membrane of the oral mucosa?

Answer 8

type 4

Question 9

where is the basement membrane in the oral mucosa?

Answer 9

between the epithelium and the mesenchyme

Question 10

what collagen type is in alveolar bone?

Answer 10

type 1

Question 11

what collagen type is in PDL?

Answer 11

type I and II

Question 12

what collagen type is in cementum?

Answer 12

type I

Question 13

what collagen type is in dentine?

Answer 13

type I

Question 14

what collagen type is in pulp?

Answer 14

type I and III

Question 15

what collagen type is in gingiva?

Answer 15

type I and IV

Question 16

what collagen type is in the TMJ?

Answer 16

type I, II and III

Question 17

what is the function of collagen in the alveolar bone?

Answer 17

resist mechanical shear from any direction

Question 18

what is the function of collagen in the PDL?

Answer 18

flexibility and strength to the tissue

Question 19

what is the function of collagen in cementum?

Answer 19

regulating periodontal tissues during development and regeneration

Question 20

what is the function of collagen in dentine?

Answer 20

accommodation of minerals in the holes and pores of fibrils

Question 21

what is the function of collagen in the pulp?

Answer 21

provides strength to connective tissue

Question 22

what is the function of collagen in the gingiva?

Answer 22

prvides strength to connective tissue

Question 23

what is the function of collagen in the TMJ?

Answer 23

structural component of intra-articular disc and provide reinforcement and mechanical stability under compression

Question 24

collagen disorders are split into 3 groups. what are they?

Answer 24

familial genetics
auto-immune
dietary

Question 25

osteogenesis imperfecta is in which group of collagen disorders?

Answer 25

familial genetics

Question 26

how does osteogenesis imperfecta affect collagen?

Answer 26

mutation in type I collagen

Question 27

what is a clinical symptom of osteogenesis imperfecta?

Answer 27

Translucent brittle teeth

Question 28

Ehlers-Danlos syndrome is in which group of collagen disorders?

Answer 28

familial genetics

Question 29

what does Ehlers-Danlos syndrome do?

Answer 29

increase elasticity

Question 30

alport syndrome is in which group of collagen disorders?

Answer 30

familial genetics

Question 31

alport syndrome affects which collagen type?

Answer 31

type IV

Question 32

what does alport syndrome cause?

Answer 32

much less basement membrane and epithelial dysplasia & fibrosis

Question 33

clinical symptom of alport syndrome

Answer 33

gingival enlargement

Question 34

stickler syndrom is in which group of collagen disorders?

Answer 34

familial genetics

Question 35

what is stickler syndrome? (tissue and collagen type)

Answer 35

Mesenchymal tissue condition from alteration of collagen type II and XI

Question 36

what is a clinical symptom of stickler syndrome?

Answer 36

cleft palate

Question 37

marfan syndrome is in which group of collagen disorders?

Answer 37

familial genetics

Question 38

what does marfan syndrome cause?

Answer 38

Excess cementum laid down

Question 39

Epidermolysis bullosa is in which groupd of collagen disorders?

Answer 39

auto-immune

Question 40

Epidermolysis bullosa affects what?

Answer 40

collagen type VII and filigrin

Question 41

Epidermolysis bullosa clinical impact?

Answer 41

easily bruise and blister

Question 42

systemic sclerosis is in which group of collagen disorders?

Answer 42

auto-immune

Question 43

what does systemic sclerosis cause?

Answer 43

Increase in the amount of skin -> oral cavity closing and less flexible Widening of periodontal space due to more matrix , increase synthesis of collagen which is less flexibl

Question 44

Lupus erythematosus is in which group of collagen disorders?

Answer 44

autoimmune

Question 45

Lupus erythematosus causes an increase in what?

Answer 45

type 7 collagen and fibronectin

Question 46

clinical symptom of lupus erythematosus

Answer 46

white pattern on the oral mucosa (lichen planus)

Question 47

Oral submucosa fibrosis is in which group of collagen disorders?

Answer 47

dietary

Question 48

what is oral submucosa fibrosis?

Answer 48

inflammatory response to alkaloid materials

Question 49

oral submucosa fibrosis causes what?

Answer 49

Epithelial thickening of the oral cavity due to more matrix (collagen) Can be potentially malignant

Question 50

what is scurvy?

Answer 50

Vitamin C deficiency causes cant produce normal collagen

Question 51

clinical impact of scurvy 3

Answer 51

Weakening of the PDL loosening of the teeth impaired dentine formation