Tissue Lecture 1 Flashcards
Cell Junctions
Purpose, Components, Types
Purpose: Connect cells to form tissues, regulate tissue homeostasis, provide tissue barrier function, facilitate cell proliferation.
Components: Interlocking transmembrane proteins.
Types: Tight junctions, Adherens junctions, Desmosomes, Hemidesmosomes, Gap junctions.
Tight Junctions
Function, Location
Function: Bind adjacent plasma membranes, prevent passage of water and solutes between cells.
Location: Stomach, intestinal tract, bladder.
Adherens Junctions
Structure, Function, Formation
Structure: Contains plaque made of actin filaments attached to cadherin proteins.
Function: Resist separation during contractile activities.
Formation: Often form extensive adhesion belts encircling cells.
Desmosomes
- Similar to adherens junctions but with specific plaque locations.
- Attach to intermediate filaments containing keratin.
- Found in epidermis and cardiac muscle cells.
Hemidesmosomes
- Anchor cells to basement membrane using integrin transmembrane protein.
- Similar structure to desmosomes but attach to laminin in the basement membrane.
Location: Between epidermis and dermis.
Gap Junctions
Composition, Function
Composition: Tunnel-like connections made of connexins.
Function: Provide intercellular communication by transferring substances like ions, nutrients, and waste products.
Epithelial Tissue
Functions, Structure, Characteristics
Functions: Protection, absorption, secretion, excretion.
Structure: Cells arranged in layers, may be single or multiple layers.
Characteristics: Avascular, ample nerve supply.
Epithelial Cell Surfaces
Apical, Lateral, Basal
Apical Surface: Faces body cavity or lumen, may contain cilia or microvilli.
Lateral Surface: Shared with adjacent cells, location of cell-to-cell junctions.
Basal Surface: Opposite to apical surface, attaches to basement membrane.
Basement Membrane
Purpose, Components
Purpose: Attaches epithelial tissue to underlying connective tissues.
Components: Basal lamina (collagen fibers, laminin, glycoproteins), reticular lamina (fibrous proteins).
Epithelium Classification
Based on, Number of cell layers, shape of cells(4)
Based on: Number of cell layers and shape of individual cells.
Number of Cell Layers: Simple (single layer), Stratified (multiple layers), Pseudostratified (appears layered but is single layer).
Shape of Cells: Squamous (flat), Cuboidal (cube-shaped), Columnar (rectangular), Transitional (able to alter between cuboidal and squamous).
Simple Epithelium
Description, Function, Examples
Description: Single layer of cells.
Function: Fast exchange across the epithelium.
Examples: Capillaries, Alveolar sacs of the lungs.
Stratified Epithelium
Description, Function, Examples
Description: Multiple layers of cells.
Function: Strength, reinforcement, protection.
Examples: Mouth, pharynx, esophagus, Skin (epidermis).
Pseudostratified Epithelium
Description, Types
Description: Appears multilayered but is actually one layer.
Types: Ciliated (respiratory tract), Non-ciliated (male reproductive tract).
Squamous
Description, Examples
Description: Flat, allows high rate of absorption.
Examples: Capillaries, Alveolar sacs of the lungs.
Cuboidal
Description
Description: Cube-shaped, may have microvilli, allows secretion and absorption.