Tissue injury and repair Flashcards
Increased demand and stimulation can lead to…
Hypertrophy & hyperplasia
E.g. left ventricular hypertrophy
Decreased nutrition and stimulation can lead to…
Atrophy
E.g. muscle shrinkage
Chronic irritation can lead to…
Metplasia
E.g. oesphogus
Tissue regeneration is…
Complete reconstitution
Tissue repair is…
Combo of regeneration and scar formation
Examples of regeneration…
Superficial skin wounds
Liver generation after partial hepatectomy
Examples of repair…
Myocardium infarc
Deep excisional wounds
Examples of fibrosis (tissue scar)…
Chronic inflam diseases (cirrhosis)
Examples of true regeneration (limited)…
Bone after fracture
Epithelium following superficial injury
Local factors that affect wound healing are…
Size
Location
Type
What can delay wound healing?
Infections
Mechanical forces
Foreign bodies
Systemic factors that affect healing are…
Nutritional status
Metabolic status
Circulatory/vascular status
Hormones
Where normal tissue architecture cannot be restored, it is mostly replaced by…
Fibrous tissue
Name complications of tissue repair…
Contractures
Excessive repair
Deficient scar formation (wound dehiscence)
What is the sequence of healing?
Inflam Angiogenesis Migration and increase amount of parenchymal cells and fibroblasts Scar formation Connective tissue remodelling
