TIN and cystic

Question 1

Three types of drug induced TIN

Answer 1

Analgesic, hypersensitivity (acute), NSAID

Question 2

Analgesic

Answer 2

chronic, necrosis of papilla (acellularity, concave)

Question 3

hypersensitivity

Answer 3

Type1 hypersens, IgE mediated w/ eosinophilia and some in urine. Damage is reversible

Question 4

ARPKD

Answer 4

fusiform cysts. In children. Usually die. Fibrocystin protein

Question 5

Medullary sponge dz

Answer 5

gravel in urine.

Question 6

Protein associated with medullary cystic dz complex

Answer 6

nephrocystin (cytoplasmic). Also problematic in ADPKD

Question 7

Genes at fault in ADPKD and what they encode

Answer 7

PKD1,2,3. Transmembrane genes (polycystin 1 and 2)

Question 8

ADPKD: presentation

Answer 8

abdomen discomfort, perhaps a blow, hematuria, cysts on liver or colon or aneurysms.

Question 9

ADPKD: pathogenesis

Answer 9

abnormal cell-matrix interaction, cell proliferation, fluid secretion (cAMP)

Question 10

Problem with polycystin 1

Answer 10

FAK protein is missing so you can’t associate with integrins