Chronic Kidney Dz

Question 1

what is a normal GFR?

Answer 1

125 mL/min

Question 2

What does serum concentration represent?

Answer 2

ration of production to elimination. In steady state, production=elimination

Question 3

why does creatinine filtration increase as GFR declines? How does this affect serum creatinine in early stages of CKD?

Answer 3

enhanced effect of secretion. It attenuates the rise in serum creatinine.

Question 4

What variables are in the GFR formulas?

Answer 4

creatinine, gender, age, ethnicity, albumin

Question 5

How does the reliability of GFR equations change with GFR?

Answer 5

less reliable as GFR increases

Question 6

definition of CKD

Answer 6

decreased kidney fxn for three months. GFR30

Question 7

Which usually comes first: proteinuria or reduced GFR?

Answer 7

proteinuria

Question 8

How is CKD related to peripheral vascular dz?

Answer 8

pro-inflammatory state, alterations in Ca and Pi.

Question 9

what is the formula for albuminuria in a 24 hr period?

Answer 9

urine albumin divided by urine creatinine. Gives you grams of albumin in 24 hrs.

Question 10

what is normal daily creatinine production

Answer 10

~1g/day