more nephritis Flashcards
Mesangial cells: two fxns and what receptors do they have
contraction, phagocytosis. AT2 receptors
what is the mechanism for nephritic edema?
you get low GFR, so low tubular flow results in Na retention
where do positively charged complexes deposit?
GBM
DPLGN: histo findings. Electron microscopy?
karyorrhexis, wire loop lesions. subendothelial deposits, paracrystalline structures (fingerprints)
Post-strep GN: nephritic or nephrotic? H/O? Special findings? Kidney surface appearance?
nephritic, strep infection. Hypercellular glomeruli and Hump like deposits (C3 and IgG). heavy influx of PMN’s (present in urine) Flea bitten (petichea)
IgA nephropathy: H/O?
Gross heamuria (URI, GI problems). Transplants.
Membranoproliferative Glomerulonephritis type 1: characteristic
hypercellular glomeruli with lobules and mesangial interposition (second BM)
Goodpasture’s Syndrome (GPS): cause, progression, characteristics. Antigen?
Anti GBM, Crescentic GN (linear GBM immunoflourescence), rapidly progressing. GP antigen in the NC1 domain of type 4 collagen
Wagener’s granulomatosis: triad? ANCA?
nasopharyngeal granuloma(nose bridge, giant cells), microscopic vasculitis, necrotizing glomerulonephritis. C-ANCA (PR3) (must be panca -)
P-ANCA: reacts w/? seen in?
MPO, crescentic glomerulonephritis. Perinuclear, popcorn appearance
Benign HTN: approx bp, age, contributing conditions, etiology. Endothelial appearance of arteries and arterioles?
> 160/90, 60y/o, diabetes, kidney isnt sensitive to bp. second arterial EL, hyalinosis of arterioles
Malignant HTN: onset, lab findings, lesions
rapid onset, younger pts, high renin levels. necrotizing and hyperplastic arteriolitis (onion skinning)
Secondary HTN: main causes
renal artery stenosis causes ischemic kidney which secretes MORE RENIN (JGA hyperplasia)
