pharm

Question 1

Aliskiren. describe effect. Good for combination therapy?

Answer 1

renin inhibitor. dose-dependent effect. monotherapy better than combining with ACEI or ARB

Question 2

-pril

Answer 2

ace inhibitor

Question 3

-sartan

Answer 3

AT2 blocker

Question 4

Aldosterone antagonists

Answer 4

spironolactone

Question 5

how does captopril work

Answer 5

competitive inhibition. fits into ace active site

Question 6

What treatments produce greatest albumin and protein reduction in urine in pts with DM?

Answer 6

ACE> CCBs, beta blockers, ARBs

Question 7

what are side effects of ACEI’s

Answer 7

Angioedema (^ bradykinin -> vasodilation and ^ vascular permeability). Cough

Question 8

what effect does losartan have in DM pts?

Answer 8

decreased albuminuria and TGF-beta1. also, decreased BP and better endpoint

Question 9

Do RAAS inhibitors cause cancer?

Answer 9

No. In fact, they may actually reduce basal and squamous cell carcinomas

Question 10

What has been proven to significantly decrease mortality in pts with LVSD? Side effects?

Answer 10

spironolactone. gynecomastia. Eplerenone doesnt cause gynecomastia

Question 11

Compare use of torsemide and furosemide. Side effects?

Answer 11

oral furosemide is erratic. Torsemide is better. Either is fine IV. Furosemide causes wasting of water soluble vitamins like thiamine causing beriberi

Question 12

when should you give vanc in a dialysis pt? Why?

Answer 12

right after dialysis.You get re equilibration from the slowly equilibrating compartment