Renal syndromes Flashcards
what is the normal range of proteinuria? microalbuminuria? nephrotic range?
3000
Acute interstitial nephritis: cause, triad
ARF as allergic rxn to new meds. Triad: rash, fever, eosinophilia
normal urine pH?
5-7
What kind of cast is found in normal urine? When do we see pigmented casts? White cell casts?
hyalin; ATN, rhabdomyolysis; Allergic Interstitial nephritis, pyelonephritis
Three classes of glomerulonephritis
Immune complex, Anti-GBM, Pauci-immune
Four Immun complex GN
IgA, Post-infectious GN, SLE, Membranoproliferative GN
IgA typical case
young asian male. rust colored urine, recent URI. has presented like this before. Blood in urine
PIGN
usually children, 2 wks after strep infection. +ASO. hematuria, proteinuria. Crescentic, humps in sub epithelium
Lupus GN
young females. rashes, arthritis, photosensitivity, ANAs. IF staining is + for all components
MPGN
Infections of herpes, HIV, leukemias.
Anti-GBM
young man exposed to hydrocarbons (gas station, smoking). Lung involvement (hemoptysis, hypoxic, SOB)
Pauci-immune diseases: name three, complement levels?
normal complement; Wegener’s, Microscopic Polyangitis, Churg-Straus
Wegener’s
About 60 yo. Upper and lower respiratory infection. C-ANCA. Triad.
MPA
about 60 yo. equal c and p anca. most common pulm-renal vasculitis. Lower lung only
Churg-Strauss
allergic granulomatosis. Asthma/eosinophilia. wheezing.
RPGN
crescentic GN w/ monocytes in bowman space. SLE and pauci-immune most likely
Fatty casts seen when?
nephrotic syndrome
MCD
explosive edema in children. foot process effacement.
FSGS
young african male. HIV, Heroin, obesity, OSA
Membranous nephropathy
associated w/ cancer, NSAIDS, gold, penicillamine. Thickened GBM, subepithelial deposits
