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Endocrine Pathology > Thyroid Carcinoma > Flashcards

Thyroid Carcinoma Flashcards

1
Q

Types of Thyroid Carcinoma

A
  1. Papillary
  2. Follicular
  3. Anaplastic
  4. Lymphoma
  5. Medullary
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2
Q

Papillary Thyroid Carcinoma

A
  • BRAF mutation or RET/PTC gene rearrangement
  • Multifocal
  • Exposure to radiation
  • Local spread to lymph nodes
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3
Q

Follicular Thyroid Carcinoma

A
  • Usually solitary nodule
  • RAS mutation of PAX8/PPARG translocation
  • Metastases to lung/bone
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4
Q

Anaplastic Thyroid Carcinoma

A
  • Aggressive

- Locally invasive

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5
Q

Lymphoma Thyroid Carcinoma

A
  • Can arise from Hashimoto’s
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6
Q

Medullary Thyroid Carcinoma

A
  • Parafollicular C cell origin
  • Sporadic, MEN2, Familial FMTC
  • Serum calcitonin levels raised
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7
Q

Thyroid Carcinoma Symptoms

A
  • Neck: lump, swelling, pain
  • Hoarseness
  • Swallowing difficulties
  • Breathing difficulties
  • Constant cough
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8
Q

Thyroid Carcinoma Staging

A

TNM

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9
Q

Thyroid Carcinoma Management

A
  • Surgery
  • Radioactive iodine (except anaplastic and medullary)
  • External radiotherapy
  • Chemotherapy
  • Suppressive thyroxine
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Endocrine Pathology (19 decks)

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