Hyperthyroidism (thyrotoxicosis) Flashcards
1
Q
Hyperthyroidism Pathology
A
Hypersecretion of TH
2
Q
Primary Hyperthyroidism Pathology
A
- Thyroid gland pathology - Grave’s disease, toxic multinodular goitre, thyroid (toxic) adenoma
- Low TSH
- Raised TH
3
Q
Secondary Hyperthyroidism Pathology
A
- TSH-secreting pituitary adenoma
- Raised TSH
- Raised TH
4
Q
Subclinical Hyperthyroidism
A
- Low TSH
- Normal TH
5
Q
Grave’s Disease Pathology
A
Antibody production which mimic TSH (bind to/block) receptor.
6
Q
Toxic Multinodular goitre
A
Characteristic goitre with absence of Grave’s disease
7
Q
Hyperthyroidism Symptoms
A
- Weight loss
- Heat intolerance (sweating)
- Muscle weakness
- Hypereflexia, tremors
- Nervousness, irritability, anxiety
- Palpitations
- Diarrhoea
- Infertility, light periods
- Difficulty sleeping
- Hair loss
- Proptosis
- Clubbing
- Gynaecomastia
8
Q
Hyperthyroidism Investigations
A
- TSH
- TFTs
- Blood test: antibodies (TSH, TPO)
- Biopsy
9
Q
Hyperthyroidism Management
A
- Antithyroid drugs
- Radioactive iodine
- Surgery
- Beta blockers/CCBs
