Acromegaly Flashcards

1
Q

Acromegaly Pathology

A

Hypersecretion of GH

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2
Q

Acromegaly Aetiology

A

Anterior pituitary somatotroph adenoma

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3
Q

Acromegaly Symptoms

A
  • Facies: course features
  • Soft tissue overgrowth: hands, feet, carpal tunnel syndrome
  • Sweating
  • Fatigue
  • Snoring
  • Joint pain
  • Sexual dysfunction
  • Headaches
  • Increased appetite/polyuria
  • Visual field defects
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4
Q

Acromegaly Complications

A
  • Osteoporosis
  • Hypertension
  • Sleep apnoea
  • Diabetes
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5
Q

Acromegaly Investigations

A
  • serum IGF-1
  • OGTT
  • serum GH
  • imaging
  • ophthalmology review
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6
Q

Acromegaly Management

A
  • Transphenoidal surgery
  • Somatostatins
  • Dopamine agonist
  • GH receptor antagonist
  • Radiotherapy
  • Testosterone
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