Thrombotic Disorders Flashcards
what are the three types of thrombosis ?
arterial
venous
microvascular
what are the three stages of haemostasis?
primary haemostats
blood coagulation
fibrinolysis
what is the “colour” of arterial thrombosis ?
white clot
what is the “colour” of venous thrombosis ?
red clot
what components make up a arterial clot?
platelets and fibrin
what components make up a venous clot?
fibrin and red cells
what are arterial thrombus commonly caused by ?
atherosclerosis
what are venous thrombus commonly caused by ?
stasis and hyper coagulation
what are two probability tests for venous thrombus?
wells
geneva
what is the lab test for venous thrombus?
d dimer
what imaging can be used for venous thrombus?
doppler
V/Q scan
CT pulmonary angiogram
what affect on tissues does arterial thrombus have?
ischaemia
infarction
how do you tell what vessel is the vein with doppler?
veins are compressible
do anti-coagulants break down clots?
no
what are anti-coagulants used for in thrombus ?
prevents the clot from getting bigger and prevents the clot to embolus
what is the management of acute presentation of arterial thromboembolism?
thrombolysis
anti-platelets/anti-coagulants drugs
what is the secondary prevention for arterial thromboembolism ?
address risk factors
statins
anti-platelets
state some risk factors for arterial thromboembolism?
age smoking sedentary lifestyle HTN DM obesity hypercholestolaemia
state some risk factors for venous thromboembolism?
age pregnancy hormonal therapy tissue trauma immobility surgery obesity systemic disease
state some systemic disease which can increase venous thromboembolus ?
cancer
myeloproliferative neoplasm
autoimmune disease
what components make up a microvascular thrombus?
platelets and fibrin
where in the body does microvascular thrombus affect?
the periphery
what is microvascular thrombus associated with?
DIC
- disseminated intravascular coagulation
state three causes of DIC?
septicaemia
malignancy
eclampsia
