thrombosis and risk factors for thrombosis Flashcards
what are the three factors of virchows triad?
blood flow
vascular endothelium
blood composition
what are the risk factors of arterial thrombosis
smoking hypertension diabetes family history obesity physical inactivity age male sex hypercholesterolaemia
what two factors play an important role in final vessel occlusion
platelet aggregation
platelet thrombi
what does the pathogenesis of venous thrombosis
venous stasis
hypercoagulable states
what percentage of dvt is clinically silent?
80%
what percentage of patients with proximal dvt have pe
50%
in those with pe have dvt?
80%
what is the rate of incidence of VTE?
1 per 1000 per annum
what is the strategy to prevent dvt?
giving appropriate prophylaxis and a consistent risk assessment
what is the nice care pathway for vte?
patient admitted to hospital assess vte risk assess bleeding risk balance risk of vte and bleeding and give prophylaxis if appropriate then reassess risk of VTE
what are are the most important risks for VTE?
active cancer or cancer treatment personal history of vte ccritical care admission surgery major trauma immobility pregnancy and postnatal period one or more significant comorbidities
what are some pharmacological prophylaxis?
heparin
fondaparinux
rivaroxaban
dabigatran
