behaviour of tumours Flashcards

1
Q

what is hypertrophy

A

enlargement in individual cell size

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2
Q

what is hyperplasia

A

increase in the number of cells

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3
Q

what is metaplasia

A

the replacement of mature tissue types

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4
Q

what is dysplasia

A

abnormality indicating precursor change of malignancy

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5
Q

what is anaplasia

A

failure to differentiate, malignancy

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6
Q

how do malignant tumours behave?

A

invasion
metastasis
angiogenesis

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7
Q

what is the difference between invasion and metastasis

A

invasion, invades adjacent normal tissue and destroys normal tissue whereas in metastasis, tumour spreads from site of origin to distant sites and forms new tumours in these new areas

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8
Q

what % of adult cancer patients have metastatic disease?

A

half of all cancer patients

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9
Q

what % of breast cancer patients have metastatic disease?

A

1/3 of breast cancer patients

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10
Q

what % of patients with basal cell carcinoma have metastatic disease

A

essentially no patients have metastatic disease

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11
Q

how do epithelial cells start to invade and migrate in cancer

A

epithelial cells gain mesenchymal properties, mesenchymal cells are loosely connected are able to migrate. this means the epithelial cells with the newly gained function can invade and migrate.

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12
Q

what is the role of proteolytic enzymes in cancer?

A

they degrade the ECM and therefore promote local invasion

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13
Q

which proteolytic enzymes degrades which type of collagen

A

interstitial collagenases degrades collagen types 1, 11, 111

gelatinises degrades collagen type IV, gelatin

stomolysins degrades collagen type IV, proteoglycans

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14
Q

what is the role of proteolytic enzymes in normal tissue regulation and how can proteolytic enzymes cause cancer?

A

normal tissue regulation is a balance between matrix metalloproteinases and tissue.

cancer favours ECM breakdown. therefore it increases matrix metalloproteinases and decreases tissue inhibitors of metalloproteinases and therefore favours ECM breakdown and therefore promotes local invasion

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15
Q

what are the routes for metastasis

A

lymphatic - distant or local lymph nodes

blood - liver, lungs, bone and brain

transcoelomic - across peritoneal, pleural, pericardial cavities or in CSF

Implantation - spillage of tumour during biopsy/surgery

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16
Q

what are the stages of metastasis

A

intravasation

detachment invasion

survival against host defences

adherence extravasation

growth

17
Q

what is the pattern of metastasis in carcinomas

A

in carcinomas, lymphatics spread first

18
Q

what is the pattern of metastasis in sarcomas

A

blood spreads first

19
Q

what is the pattern of metastasis in bone metastases

A

spreads to breast, prostate, lung, kidney and thyroid

20
Q

what is the pattern od metastasis in transcoelomic metastasises

A

ovarian

21
Q

what is the mechanical hypothesis in patterns of metastasis

A

the mechanical hypothesis is directed by anatomy e.g. lymphatic drainage, liver mets in GI cancer

22
Q

what is the seed and soil hypothesis in patterns of metastasis?

A

when a plant goes to seed, its seeds are carried in all directions; but they can only live and grow if they fall on congenial soil.

23
Q

when is angiogenesis particularly important.

A

angiogenesis is essential if metastases are to grow larger than 1-2 mm

24
Q

why stage and grade cancer?

A

determine prognosis - survival time, quality of life

decides how to treat the tumour

research- it allows us to compare therapies or prognostic factors

25
Q

how are tumours staged

A

tumours are staged using TMN system ]

T- size +/- extent of primary tumour
M- prescience and extent of distant metastases
N -prescence and number of lymph Node metastases

26
Q

By what basic mechanisms do tumour cells start to invade local tissues?

A

1) Increased motility
2) Decreased adhesion
3) Mechanical pressure
4) Production of proteolytic enzymes

27
Q

What are the 2 classes of adhesion molecule which are lost in malignant cells?

A

Cell to cell adhesion molecules - cadherins

Cell to matrix adhesion molecules - integrins

28
Q

What changes occur leading to a reduction in adhesion of malignant cells?

A

Mutation of E-cadherin in malignant cells leads to loss of cell-cell adhesion and contact inhibition
Changes in integrin expression in malignant cells lead to decreased cell-matrix adhesion

29
Q

Are metalloproteinases produced by healthy cells?

A

Yes, they play a role in normal tissue regulation and are balanced by tissue inhibitors of metalloproteinases

30
Q

What is the role of metalloproteinases in normal tissue regulation?

A

Needed to mop up collagen and remodel tissues etc.

31
Q

How does mechanical pressure contribute to invasion?

A

Uncontrolled proliferation forms a mass
Pressure occludes vessels
Get pressure atrophy
Tumour spreads along the line of least resistance

32
Q

What are the cell to cell adhesion molecules?

A

cadherins

33
Q

What are the cell to matrix adhesion molecules?

A

integrins

34
Q

What is the difference between epithelial cells and mesenchymal cells?

A

Epithelial cells - tightly connected, polarised and tethered

Mesenchymal cells - loosely connected, able to migrate

35
Q

What are matrix metalloproteinases?

A

Enzymes responsible for the degradation of most extracellular matrix proteins

36
Q

What does the transcoelomic route of metastasis mean?

A

Across peritoneal, pleural, pericardial cavities or in CSF