behaviour of tumours Flashcards
what is hypertrophy
enlargement in individual cell size
what is hyperplasia
increase in the number of cells
what is metaplasia
the replacement of mature tissue types
what is dysplasia
abnormality indicating precursor change of malignancy
what is anaplasia
failure to differentiate, malignancy
how do malignant tumours behave?
invasion
metastasis
angiogenesis
what is the difference between invasion and metastasis
invasion, invades adjacent normal tissue and destroys normal tissue whereas in metastasis, tumour spreads from site of origin to distant sites and forms new tumours in these new areas
what % of adult cancer patients have metastatic disease?
half of all cancer patients
what % of breast cancer patients have metastatic disease?
1/3 of breast cancer patients
what % of patients with basal cell carcinoma have metastatic disease
essentially no patients have metastatic disease
how do epithelial cells start to invade and migrate in cancer
epithelial cells gain mesenchymal properties, mesenchymal cells are loosely connected are able to migrate. this means the epithelial cells with the newly gained function can invade and migrate.
what is the role of proteolytic enzymes in cancer?
they degrade the ECM and therefore promote local invasion
which proteolytic enzymes degrades which type of collagen
interstitial collagenases degrades collagen types 1, 11, 111
gelatinises degrades collagen type IV, gelatin
stomolysins degrades collagen type IV, proteoglycans
what is the role of proteolytic enzymes in normal tissue regulation and how can proteolytic enzymes cause cancer?
normal tissue regulation is a balance between matrix metalloproteinases and tissue.
cancer favours ECM breakdown. therefore it increases matrix metalloproteinases and decreases tissue inhibitors of metalloproteinases and therefore favours ECM breakdown and therefore promotes local invasion
what are the routes for metastasis
lymphatic - distant or local lymph nodes
blood - liver, lungs, bone and brain
transcoelomic - across peritoneal, pleural, pericardial cavities or in CSF
Implantation - spillage of tumour during biopsy/surgery