thrombosis and embolism Flashcards
what is stasis blood flow
stagnation of blood flow
what is turbulence in relation to blood flow
forceful, unpredictable blood flow
what defects occur in blood flow
thromboembolism
atheroma
hyperviscosity
spasm
external compression
vasculitits
vascular steal
what is vascular steal
when the effects of stenosis are exhazarrbated because of excersise and redirection of blood
what are the 3 parts of virchows triad
changes in the blood vessel wall
changes in the bloos constituents (platlets, RBCs, WBCs)
changes in the pattern of blood flow
what do virchows triad do
the factors causing thrombosis
what is the definition of a thrombus
formation of a solif mass from the constituents of blood WITHIN the vascular system DURING LIFE
what is the definition of a clot
formation of mass from the constitiuents of blood
either OUTSIDE the vascular system
or inside the vascular system AFTER DEATH
what is the factor that causes thrombus formation (thrombosis)
changes in the vessel wall
what are 3 main parts of pathogenesis of thrombosis
VIRCHOWS TRIAD
endothelial injury
stasis or turbulent blood flow
hypercoaguablitity of the blood
what happens to a atheromatous coronary artery to form a thrombus
turbulent blood flow, loss of intimal cells,
collagen exposed - platelets adhere, fibrin meshwork RBCs trapped
what are examples of the virkos triad relating to change in constituents
hyperlipdeamia
hyper viscosity
post- traumatic hypercoagulablity
what are some examples of changes in blood flow (virkows triad)
stasis - economy class syndrome
turbulence - atheromatous plaque, aortic aneurysm
what do the consequences of a thrombus depend on
site
extent
collateral circulation
what are the outcomes of a thrombus
resolution (small thrombus)
organasation/recanulisation
propagation (forming an embolism)
death
what is the definition of embolism
movment of abnormal material in the blood stream that then gets lodged (inpactation) in a vessel blocking its lumen