Thrombosis

Question 1

For VTE which thrombophilias have the highest risk of thrombosis?

Answer 1

ATIII has a 20 fold increased risk. While Protein C and S have a 10 fold risk.

Question 2

What is the risk of VTE associated with Factor V Leiden?

Answer 2

A 3-8 fold risk of thrombosis

Question 3

What is the prescription regimen for Xarelto in the initial treatment of VTE?

Answer 3

15mg BID for 3 weeks followed by 20mg daily with food.

Question 4

What is the prescription for VTE when using Eliquis for an initial VTE?

Answer 4

10mg BID for one week followed by 5mg BID daily

Question 5

What is the recommendation for patients who are pregnant if they developed a VTE unprovoked or on hormonal therapy?

Answer 5

These patients will require antepartum and postpartum anti coagulation (for 3 months postpartum).

Question 6

What is the recommendation for pregnant women who are heterozygous for factor V Leiden or Prothrombin gene mutation?

Answer 6

Regardless of family history these patients do not require anti coagulation antepartum or postpartum!

Question 7

What is the recommendation for anti coagulation in pregnancy for protein C deficiency?

Answer 7

In the antepartum period it is not recommended regardless of family history while in the postpartum period it is recommended if there is a family history.

Question 8

What is the recommendation for anticoagulation in pregnancy for protein S deficiency?

Answer 8

It is not recommended in the antepartum period but in the postpartum period if there is a family history it is recommended.