AML Flashcards
What cytogenetic abnormalities qualify as AML regardless of the blast count?
t(8;21), inv (16), t(16;16), and t(15;17)
What are some favorable risk cytogenetics for AML?
Biallelic mutated CEBPA, mutated NPM1 w/o FLT3 ITD or with FLT3 ITD low, inv 16, t(16;16), t (8;21) RUNX1/RUNX1T1
Wild type NPM1 and FLT-3 ITD high confer what kind of risk in AML?
High risk disease!
Mutated RUNX1, ASXL1, and TP53 mutation carry what kind of risk in AML?
High risk disease
In regards to NPM1 mutations what are the combinations that give you intermediate risk disease?
Mutated NPM1 and FLT3 ITD high, wild type NPM w/o FLT-3 ITD or with FLT3-ITD low
What is the typical translocation found in APL?
t(15;17) PML;RARA
What is a atypical chromosome translocation that can be seen in APL? What is the clinical significance?
t(11;17) This translocation is not responsive to ATRA, you will need to use AML directed chemo
What is defined as high risk APL and what is the tx?
Greater than 10 K WBC, you start dexamethasone.
What are the flow results for APL?
HLA-DR-, CD33, CD13+, CD34-
What are the tx options for high risk APL?
ATRA/ATO plus Gemtuzumab Ozogamicin
ATRA/ATO plus Idarubicin or Daunarubicin
What is the induction regimen used for FLT3 ITD or TKD?
- 7+3 (dauno or Ida) w/midostaurin (ITD or TKD)
- 7+3 (dauno or Ida) w quizartinib (ITD only)
What induction regimens do you use for low risk AML?
- 7+3 (daunorubicin)+Gemtuzumab (preferred regimen).
- 7+3 (w/daunorubicin or Ida)
- 7+3 (mitoxantrone)
What is tx for intermediate risk AML?
7+3 (dauno or Ida)
7+3 (mitoxantrone) for 60 and older
What is the induction regimen preferred for TP53 and/or del17p?
- 7+3 (cat 1 rec)
- 7+3 (mitoxantrone) for 60 and older
- HiDAC+ dauno or Ida+ Etoposide (cat 1 rec)
What is the tx for therapy induced AML or antecedent MDS/CMML or MDS related cytogenetic changes (that define AML)?
- 7+3
- Vyxeos (liposomal daunorubicin and cytarabine) (only for age 60 or older)
- Azacitidine or Decitabine w/Venetoclax