Iron Deficiency Flashcards
1
Q
Where is hepcidin produced and what stimulates its production? What is the end result?
A
It is produced in hepatocytes. It is secreted in response to inflammation and increased iron stores. It causes decreased iron absorption in the gut. It degrades ferroportin.
2
Q
What is the result of the TMPRSS6 (Matriptase-2) mutation?
A
Inactivating mutations lead to abnormally increased hepcidin and reduced iron absorption. It is autosomal recessive. There is no response to oral iron and a partial response to IV iron