ABO Incompatibility in HSCT

Question 1

What medication can you use for pure red cell aplasia that happens in patients undergoing HSCT?

Answer 1

Daratumumab

Question 2

What CD molecule and on what cells does Daratumumab target?

Answer 2

CD38 on plasma cells and plasmablasts.

Question 3

What is a side effect seen with Daratumumab in the setting of pure red cell aplasia with a HSCT?

Answer 3

Hypogammaglobulinemia.

Question 4

When dealing with ABO incompatibility with a SCT and a patient needs a blood transfusion in the setting of a major ABO mismatch what blood type should the patient receive?

Answer 4

The blood transfusion should be of the recipients blood type.

Question 5

When dealing with a minor ABO mismatch in the setting of a transplant, what blood product should the patient receive?

Answer 5

For a minor mismatch the patient should receive the donors blood type.

Question 6

In the setting of a major ABO mismatch with a transplant, what type of plasma product do you give?

Answer 6

You give plasma of the donor blood type.

Question 7

In the setting of minor ABO mismatch with a transplant, what type of plasma product do you give?

Answer 7

You give the recipients blood type.

Question 8

In the setting of a bidirectional mismatch what type of blood product and plasma product do you give?

Answer 8

Blood-O type always!
Plasma-AB type always!