Thromboembolism

Question 1

what does heparin inactivate

Answer 1

Factor Xa and thrombin

Question 2

what converts fibrinogen to fibrin

Answer 2

thrombin

Question 3

dalteparin class

Answer 3

Low molecular weight heparins (LMWH)

Question 4

what does dalteparin target

Answer 4

Antithrombin III

Question 5

dalteparin inhibits

Answer 5

factor Xa in the common pathway of the clotting cascade

Question 6

what is factor X1 used for

Answer 6

convert prothrombin to thrombin

Question 7

dalteparin bad side effects

Answer 7

Haemorrhage
thrombocytopenia (HIT)
Hyperkalaemia

Question 8

what is Antithrombin III

Answer 8

a serine protease inhibitor

Question 9

Fondaparinux inhibits

Answer 9

Factor Xa

Question 10

Fondaparinux binds to

Answer 10

ATIII

Question 11

Warfarin class

Answer 11

Vitamin K antagonist

Question 12

Warfarin targets

Answer 12

Vitamin K epoxide reductase

Question 13

Warfarin depletes which factors

Answer 13

II, VII, IX and X

Question 14

how long does it take Warfarin to work

Answer 14

days until already formed active clotting factors have been degraded

Question 15

Warfarin patients get what checked

Answer 15

INR

Question 16

Warfarin and pregnancy

Answer 16

Warfarin can cross the placental barrier during pregnancy resulting in foetal bleeding, spontaneous abortion, and neonatal death

Question 17

rivaroxaban targets

Answer 17

Factor Xa

Question 18

rivaroxaban inhibits

Answer 18

activated factor Xa

Question 19

Dabigatran class

Answer 19

direct thrombin (factor II) inhibitor

Question 20

rivaroxaban bad side effects

Answer 20

Hepatobiliary disorders (dabigatran) 
Renal impairment (rivaroxaban)

Question 21

apixaban moa

Answer 21

directly inhibiting, in a reversible manner, free and clot-bound factor Xa to inhibit coagulation