Thromboembolism Flashcards
what does heparin inactivate
Factor Xa and thrombin
what converts fibrinogen to fibrin
thrombin
dalteparin class
Low molecular weight heparins (LMWH)
what does dalteparin target
Antithrombin III
dalteparin inhibits
factor Xa in the common pathway of the clotting cascade
what is factor X1 used for
convert prothrombin to thrombin
dalteparin bad side effects
Haemorrhage
thrombocytopenia (HIT)
Hyperkalaemia
what is Antithrombin III
a serine protease inhibitor
Fondaparinux inhibits
Factor Xa
Fondaparinux binds to
ATIII
Warfarin class
Vitamin K antagonist
Warfarin targets
Vitamin K epoxide reductase
Warfarin depletes which factors
II, VII, IX and X
how long does it take Warfarin to work
days until already formed active clotting factors have been degraded
Warfarin patients get what checked
INR
Warfarin and pregnancy
Warfarin can cross the placental barrier during pregnancy resulting in foetal bleeding, spontaneous abortion, and neonatal death
rivaroxaban targets
Factor Xa
rivaroxaban inhibits
activated factor Xa
Dabigatran class
direct thrombin (factor II) inhibitor
rivaroxaban bad side effects
Hepatobiliary disorders (dabigatran) Renal impairment (rivaroxaban)
apixaban moa
directly inhibiting, in a reversible manner, free and clot-bound factor Xa to inhibit coagulation
